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![Mortal Secrets Freud, Vienna, and the Discovery of the Modern Mind [Audiobook]](https://i123.fastpic.org/big/2024/0410/71/7060ec9024afdd1b65b82ac6ee869771.jpeg) Free Download Mortal Secrets: Freud, Vienna, and the Discovery of the Modern Mind (Audiobook) English | ASIN: B0CV4HT1XW | 2024 | 14 hours and 12 minutes | M4B@64 kbps | 412 MB Author: Frank Tallis Narrator: Simon Shepherd A chronicle of Vienna's Golden Age and the influence of Sigmund Freud on the modern world by a clinical psychologist whose mystery novels form the basis of PBS's Vienna Blood series. Some cities are like stars. When the conditions are right, they ignite, and burn with such fierce intensity that they outshine every other city on the planet. Vienna was one such city and, at the beginning of the twentieth century, was the birthplace of the modern mind and the way we live today. Long coffee menus and celebrity interviews are Viennese inventions. 'Modern' buildings were appearing in Vienna long before they started appearing in New York and the idea of practical modern home design originated in the work of Viennese architect Adolf Loos.  Free Download Jürgen Blunck, "Solar System Moons: Discovery and Mythology" English | 2009 | pages: 148 | ISBN: 3540688528, 3642448429 | PDF | 2,4 mb Starting from Mars outward this concise handbook provides thorough information on the satellites of the planets in the solar system. Each chapter begins with a section on the discovery and the naming of the planet's satellites or rings. This is followed by a section presenting the historic sources of those names. The book contains tables with the orbital and physical parameters of all satellites and is illustrated throughout with modern photos of the planets and their moons as well as historical and mythological drawings. The Cyrillic transcriptions of the satellite names are provided in a register.  Free Download José L. Balcázar, Francesco Bonchi, Aristides Gionis, "Machine Learning and Knowledge Discovery in Databases, Part I" English | 2010 | pages: 647 | ISBN: 364215879X | PDF | 11,8 mb The European Conference on Machine Learning and Principles and Practice of Knowledge Discovery in Databases, ECML PKDD 2010, was held in Barcelona, September 20 24, 2010, consolidating the long junction between the European Conference on Machine Learning (of which the ?rst instance as European wo- shop dates back to 1986) and Principles and Practice of Knowledge Discovery in Data Bases (of which the ?rst instance dates back to 1997). Since the two conferences were ?rst collocated in 2001, both machine learning and data m- ing communities have realized how each discipline bene?ts from the advances, and participates to de?ning the challenges, of the sister discipline. Accordingly, a single ECML PKDD Steering Committee gathering senior members of both communities was appointed in 2008. In 2010, as in previous years, ECML PKDD lasted from Monday to F- day. It involved six plenary invited talks, by Christos Faloutsos, Jiawei Han, Hod Lipson, Leslie Pack Kaelbling, Tomaso Poggio, and Jur ] gen Schmidhuber, respectively. Monday and Friday were devoted to workshops and tutorials, or- nized and selected by Colin de la Higuera and Gemma Garriga.Continuing from ECML PKDD 2009, an industrial session managed by Taneli Mielikainen and Hugo Zaragoza welcomed distinguished speakers from the ML and DM ind- try: Rakesh Agrawal, Mayank Bawa, Ignasi Belda, Michael Berthold, JoseLuis Fl orez, ThoreGraepel, andAlejandroJaimes.Theconferencealsofeaturedad- coverychallenge, organizedbyAndr asBenczur, CarlosCastillo, Zolt anGyon ] gyi, and Julien Masan es."  Free Download Yee Leung, "Knowledge Discovery in Spatial Data (Advances in Spatial Science)" English | 2009 | pages: 381 | ISBN: 364202663X, 3642261701 | PDF | 10,6 mb When I ?rst came across the term data mining and knowledge discovery in databases, I was excited and curious to ?nd out what it was all about. I was excited because the term tends to convey a new ?eld that is in the making. I was curious because I wondered what it was doing that the other ?elds of research, such as statistics and the broad ?eld of arti?cial intelligence, were not doing. After reading up on the literature, I have come to realize that it is not much different from conventional data analysis. The commonly used de?nition of knowledge discovery in databases: "the non-trivial process of identifying valid, novel, potentially useful, and ultimately understandable patterns in data" is actually in line with the core mission of conventional data analysis. The process employed by conventional data analysis is by no means trivial, and the patterns in data to be unraveled have, of course, to be valid, novel, useful and understandable. Therefore, what is the commotion all about? Careful scrutiny of the main lines of research in data mining and knowledge discovery again told me that they are not much different from that of conventional data analysis. Putting aside data warehousing and database m- agement aspects, again a main area of research in conventional database research, the rest of the tasks in data mining are largely the main concerns of conventional data analysis.  Free Download Flipons: The Discovery of Z-DNA and Soft-Wired Genomes English | 2024 | ISBN: 1032731087 | 228 Pages | PDF (True) | 328 MB Alan Herbert has played a leading part in discovering the biological roles for a high-energy form of DNA twisted to the left rather than to the right. Both Z-DNA and the Z-RNA sensing proteins are critical for protecting hosts against both viruses and cancers. The proteins also play critical roles in the programmed cell death of aging cells. Other types of flipons exist and alter the readout of transcripts from the genome, encoding genetic information by their shape rather than by their sequence. Many of these flipons are within repeat elements that were previously considered to be just genomic junk. Instead these genetic elements increase the adaptability of cells by flipping DNA conformation. By acting as digital switches, the different flipon types can alter cellular responses without any change to their sequence or any damage to DNA. These highly dynamic structures enable the rapid evolution of multicellular organisms. The junk DNA in repeats also encode peptide patches that enable the assembly of cellular machines. The intransitive logic involved enhances the chance of an individual surviving a constantly changing environment.  Free Download Kelly Chibale, Mike Davies-Coleman, Collen Masimirembwa, "Drug Discovery in Africa: Impacts of Genomics, Natural Products, Traditional Medicines, Insights into Medicinal Chemistry, and Technology Platforms in Pursuit of New Drugs" English | 2012 | pages: 453 | ISBN: 3642281745, 3642430228 | PDF | 8,7 mb Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa. Compiled by leading African and international experts, this book presents the science and strategies of modern drug discovery. It explores how the use of natural products and traditional medicines can benefit from conventional drug discovery approaches, and proposes solutions to current technological, infrastructural, human resources, and economic challenges, which are presented when attempting to engage in full-scale drug discovery. Topics addressed are varied; from African medicinal plants to marine bioprospecting, pharmacogenetics and the use of nanotechnology. This book brings together for the first time a collection of strategies and techniques that need to be considered when developing drugs in an African setting. It is an unprecedented and truly international effort, highlighting the remarkable effort made so far in the area of drug discovery research by African scientists, and scientists from other parts of the world working on African health problems.  Free Download Gerhard H. Vogel, Hans G. Vogel, Dieter Mayer, Gerhard H. Vogel, "Drug Discovery and Evaluation: Pharmacological Assays" English | 2008 | pages: 2117 | ISBN: 3540256385, 3540423966 | PDF | 22,0 mb Safety aspects have become an outstanding issue in the process of drug discovery and development. Until 15 years ago, drug discovery and evaluation was a sequential process starting with the selection of the most active compound from a series of newly synthesized compounds by means of special pharmacological assays. Safety aspects were addressed by pharmacological testing of the selected compound in high doses in tests directed at indications other than the intended indication of the new compound. These tests were followed by pharmacokinetic studies, which were mainly aimed at confirming of a suitable half-life time and at oral activity. Safety aspects relied mostly on toxicity studies, which however gave information on changes of organ structure rather than on organ function. Toxicological and pharmacokinetic studies were adapted to the progress of studies in clinical pharmacology and clinical trails. This "sequential" strategy has been abandoned for several reasons: - Some negative effects on organ function, e.g. ventricular tachy-arrhythmia, were detected too late. On the other hand, negative findings in chronic toxicity studies in animals turned out to be irrelevant for human beings.- New scientific approaches, e.g. combinatorial chemistry, high-throughput screening, in silico models, pharmaco-genomics and pharmaco-proteomics offered new possibilities.- There are several examples which show that the "druggability" of compounds was considerably underestimated when the probability of success of a new project was assessed.The success rate in the pharmaceutical industry and the introduction of new chemical entities to the market per year dropped dramatically, whereas the development time for a new compound increased, sometimes exceeding the patent protection. A change of strategy was therefore adopted, involving the following changes: - Parallel instead of sequential involvement of the various disciplines (multidimensional compound optimization).- The term "Safety Pharmacology" was coined. The International Conference on Harmonization (ICH) founded a Safety Pharmacology Working Group. Easily accessible and the most informative tests now have to be selected.- Exposure of a drug to the body by pharmacokinetic studies on absorption, distribution, metabolism and excretion has to be investigated at an early stage of development and can contribute to the selection of a compound for development. Toxicology experienced major achievements by the introduction of new methods, e.g., in silico methods, toxicogenomics and toxicoproteomics.The book is a landmark in the continuously changing world of drugs. As such it is important reading for many groups: not only for all students of pharmacology and toxicology but also for physicians, especially those involved in clinical trials of drugs, and for pharmacists who have to know the safety requirements of drugs.The book is absolutely essential for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.In particular, the book will be of use for government institutions and committees working on official guidelines for drug evaluation worldwide.  Free Download Creative Machine Knitting: A Voyage of Discovery into Colour, Shape and Stitches by Alison Dupernex English | August 1, 2023 | ISBN: 0719840996 | 272 pages | PDF | 67 Mb Creative Machine Knitting is simply a treasure trove for machine knitters; overflowing with design ideas and stitch patterns to inspire you to explore different styles and to make wonderful new projects. Knit with an open mind and be prepared to have a go, make changes and look to improvise - push yourself out of your comfort zone. Topics covered include; how to design - from where to source inspiration, consideration of materials and adoption of sustainable practices; painting with yarn - the process of translating a pattern or colour scheme into a knitted fabric; designing with panels and borders, and adding embellishments; Fairisle - advice on colour selection and pattern placement, including a 'sketchbook' of over fifty stitch patterns to try and finally, there is an inspiring stitch pattern directory of even more examples, illustrating the endless possibilities available to the machine knitter. The book features over 100 patterns, all of which can be adapted and form the basis of new designs, covering: jackets, cardigans and kimonos; sweaters; Fairisle designs; waistcoats; children's knitwear; accessories and homewares.  Free Download A Beginner'S Guide To Self–Discovery Published 3/2024 MP4 | Video: h264, 1920x1080 | Audio: AAC, 44.1 KHz Language: English | Size: 1.69 GB | Duration: 0h 56m Live on your terms – Break free from external expectations  Free Download ServiceNow CMDB & Discovery Genius Published 3/2024 Created by O P Singh MP4 | Video: h264, 1280x720 | Audio: AAC, 44.1 KHz, 2 Ch Genre: eLearning | Language: English | Duration: 11 Lectures ( 3h 16m ) | Size: 1.9 GB |
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