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 Resistance to Targeted Therapies in Multiple Myeloma English | 2021 | ISBN: 3030734390 | 171 Pages | PDF EPUB | 3 MB Multiple Myeloma remains an incurable malignancy. As the disease progresses, it invariably becomes resistant to treatment and almost all patients develop refractory disease. There are multiple different types of targeted therapies and many of them are used in combination at different stages of disease. Targeted therapies that are approved to be used include Proteasome Inhibitors, Immunomodulatory Drugs and Monoclonal Antibodies. Second and third generations of these drugs are developed to overcome resistance and they have unique mechanism of actions. Targeted therapies that are undergoing clinical trials include CAR-T cells, bi-specific antibodies, vaccines, ubiquitin ligase inhibitors and BCL-2 inhibitors.
 Lisa Herzog, "Reclaiming the System: Moral Responsibility, Divided Labour, and the Role of Organizations in Society" English | ISBN: 0198830408 | 2019 | 336 pages | PDF | 2 MB The world of wage labour seems to have become a soulless machine, an engine of social and environmental destruction. Employees seem to be nothing but 'cogs' in this system - but is this true? Located at the intersection of political theory, moral philosophy, and business ethics, this book  Radetzky's Marches: The Campaigns of 1848 and 1849 in Upper Italy By Michael Embree 2013 | 470 Pages | ISBN: 1909384399 | EPUB | 21 MB In the spring of 1848, revolution threatened to sweep away the old order throughout Europe. In the Austrian-occupied north of Italy, newly nurtured nationalism, further fueled by economic issues, prompted open revolt in Lombardy and Venetia. The Austrian army in Italy, commanded by 82-year-old Field Marshal Radetzky, soon saw itself under further threat from the Kingdom of Sardinia-Piedmont, that of Naples, and the Papal States, as well as thousands of volunteers, all determined to rid Italy of the occupier. Seemingly under attack from all sides, the Austrian Army was forced to concentrate in the famous 'Quadrilateral', formed by the fortress cities of Peschiera, Mantua, Legnago, and Verona, losing deserters by the thousand, to prepare for the war to follow, a war that would continue into the following year. This volume narrates the remarkable tale of how one old general quite possibly saved an empire. With iron will, the great personal affection of his men, and some luck, Radetzky maintained his army, and finally defeated his opponents. Such was the impact of the 1848 campaign, that Johann Strauss the Elder wrote the 'Radetzky March', in the Field Marshal's honor! The comprehensive story of the revolts and the subsequent military campaigns is recounted here, taken from many and varied sources, including a considerable number of contemporary and first-hand accounts, as well official reports from all sides. Radetzky's Marches is profusely illustrated, and is accompanied by maps, charts, diagrams and extensive orders-of-battle.
 Python Made Easy: Step By Step Guide To Programming And Data Analysis Using Python For Beginners And Intermediate Level by Nilabh Nishchhal English | October 20th, 2020 | ISBN: 1649837259 | 436 pages | True EPUB | 21.59 MB Python Made Easy: Beginners Guide to Programming and Data Analysis using Python  Product Strategy: Mastering the Basics and dominating the competition by Gary Metcalfe English | October 11, 2018 | ISBN: 1728684897 | 110 pages | EPUB | 0.32 Mb [b]So you have a great product. Guess what? Your competitors have one as well.  Pharmaceutical and Medical Devices Manufacturing Computer Systems Validation By Orlando López 2018 | 344 Pages | ISBN: 1138041181 | PDF | 5 MB Validation of computer systems is the process that assures the formal assessment and report of quality and performance measures for all the life-cycle stages of software and system development, its implementation, qualification and acceptance, operation, modification, requalification, maintenance and retirement (PICS CSV PI 011-3). It is a process that demonstrates the compliance of computer systems functional and non-functional requirements, data integrity, regulated company procedures and safety requirements, industry standards, and applicable regulatory authority's requirements. Compliance is a state of being in adherence to application-related standards or conventions or regulations in laws and similar prescriptions.This book, which is relevant to the pharmaceutical and medical devices regulated operations, provides practical information to assist in the computer validation to production systems, while highlighting and efficiently integrating worldwide regulation into the subject. A practical approach is presented to increase efficiency and to ensure that the validation of computer systems is correctly achieved.  One Dish Fish: Quick and Simple Recipes to Cook in the Oven by Lola Milne English | ISBN: 0857839489 | 160 pages | EPUB | July 22, 2021 | 26 Mb Cooked in the oven in just one dish or roasting tin, all the recipes here are ready within 20, 30 or 45 minutes, allowing you to enjoy a wide variety of fish and seafood with no faff or fiddle.  Once They Were Hats: In Search of the Mighty Beaver By Frances Backhouse 2015 | 256 Pages | ISBN: 1770412077 | EPUB | 2 MB Finalist for the 2015 Lane Anderson Award and the 2016 Butler Book PrizeBeavers, those icons of industriousness, have been gnawing down trees, building dams, shaping the land, and creating critical habitat in North America for at least a million years. Once one of the continent's most ubiquitous mammals, they ranged from the Atlantic to the Pacific, and from the Rio Grande to the edge of the northern tundra. Wherever there was wood and water, there were beavers - 60 million (or more) - and wherever there were beavers, there were intricate natural communities that depended on their activities. Then the European fur traders arrived.In Once They Were Hats, Frances Backhouse examines humanity's 15,000-year relationship with Castor canadensis, and the beaver's even older relationship with North American landscapes and ecosystems. From the waterlogged environs of the Beaver Capital of Canada to the wilderness cabin that controversial conservationist Grey Owl shared with pet beavers, Backhouse goes on a journey of discovery to find out what happened after we nearly wiped this essential animal off the map, and how we can learn to live with beavers now that they're returning. |
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