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 English | 2022 | ISBN: 3030909891 | 349 pages | True PDF EPUB | 54.39 MB This is a book about software engineering, bioinformatics, the C++ programming language and the SeqAn library. In the broadest sense, it will help the reader create better, faster and more reliable software by deepening their understanding of available tools, language features, techniques and design patterns. Every developer who previously worked with C++ will enjoy the in-depth chapter on important changes in the language from C++11 up to and including C++20. In contrast to many resources on Modern C++ that present new features only in small isolated examples, this book represents a more holistic approach: readers will understand the relevance of new features and how they interact in the context of a large software project and not just within a "toy example". Previous experience in creating software with C++ is highly recommended to fully appreciate these aspects.  English | 2022 | ISBN: 3030951480 | 168 pages | True PDF EPUB | 5.45 MB These days, the idea of "value" is at the center of many activities and decisions in health care in the United States. While there exist books that detail the technical steps for how to carry out a specific type of value assessment, such as cost-effectiveness or return on investment, there are few that attempt to teach healthcare professionals how to think about value. This book provides a deeper understanding of value as a concept as well as an endeavor (as in, to determine or uncover the value of care) within the healthcare industry by illustrating the different components of value that should guide decision-making processes for policy, infrastructure, and quality improvement. Through an exploration of theories of economics and implementation science, as well as practical suggestions for real-world applications, this text provides a foundation for the long and complicated "value" journey the US has bet its entire healthcare system on. In the US, policy to promote what is referred to as "value-based care" is here to stay. As we move forward within this construct, we need to move beyond the over-simplified definition of value as "quality per dollar spent" to a more functional framework for how to think about value that can adapt to different circumstances and points of view. Only then will it be possible to compare value across settings, conditions, and activities.  English | 2022 | ISBN: 1009098403 | 143 pages | PDF | 13.67 MB Anyone browsing at the stationery store will see an incredible array of pop-up cards available for any occasion. The workings of pop-up cards and pop-up books can be remarkably intricate. Behind such designs lies beautiful geometry involving the intersection of circles, cones, and spheres, the movements of linkages, and other constructions. The geometry can be modelled by algebraic equations, whose solutions explain the dynamics. For example, several pop-up motions rely on the intersection of three spheres, a computation made every second for GPS location. Connecting the motions of the card structures with the algebra and geometry reveals abstract mathematics performing tangible calculations. Beginning with the nephroid in the 19th-century, the mathematics of pop-up design is now at the frontiers of rigid origami and algorithmic computational complexity. All topics are accessible to those familiar with high-school mathematics; no calculus required. Explanations are supplemented by 140+ figures and 20 animations. [center]  English | 2022 | ISBN: 3030947351 | 528 pages | True PDF EPUB | 7.18 MB This book presents a comprehensive analysis of the alterations and problems caused by new technologies in all fields of politics. It further examines the impact of artificial intelligence (AI) on the nexus between politics, economics, and law. The book raises and answers several important questions: What is the role of AI in politics? Are people prepared for the challenges presented by technical developments? How will Al affect future politics and human society? How can politics and law deal with Al's disruptive technologies? What impact will AI and technology have on law? How can efficient cooperation between human beings and AI be shaped? Can artificial intelligence automate public decision-making?  English | 2022 | ISBN: 3030833941 | 436 pages | True PDF EPUB | 59.14 MB A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery systems. No other consolidated published reference discusses the PK/PD study of nanoparticle drug delivery systems. This book discusses the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of many drugs that are not easily metabolized or that obtain the desired therapeutic effect with minimum toxicity. The authors provide an overview of biodistribution with a focus on polymer and lipid nanoparticles. This thorough reference is divided into three parts: Modelling, Specific carries and their potential to treat specific diseases.  English | 2022 | ISBN: 3030748030 | 333 pages | True PDF EPUB | 10.13 MB This book offers a multidisciplinary look at the much-debated concept of "personalized medicine". By combining a humanistic and a scientific approach, the book builds up a multidimensional way to understand the limits and potentialities of a personalized approach in medicine and healthcare. The book reflects on personalized medicine and complex diseases, the relationship between personalized medicine and the new bio-technologies, personalized medicine and personalized nutrition, and on some ethical, political, economic, and social implications of personalized medicine. This volume is of interest to researchers from several disciplines including philosophy, bio-medicine, and the social sciences. [center]  English | 2022 | ISBN: 1032013133 | 197 pages | True PDF | 4.31 MB Personalising Trauma Treatment is about helping trauma victims back to their old selves and focuses on altering the perception of the centrality of the trauma. In this book, clients are taught to rediscover their sense of self by reframing the trauma. Within this new framework the focus is on the client's mental time travel from the trauma to today and reimagining their future. The therapeutic targets are the thoughts and images (cognitions) that interfere with day-to-day functioning. It does not assume that arrested information processing lies at the heart of the development of PTSD, with a consequent need for the client to re-live the trauma. For those clients who were abused in childhood, their experiences are viewed through a particular central window, but other 'windows' may make for more appropriate engagement with their personal world and a reimagining of their view of themselves. Treatment delivery options from telephone consultation, group work and videoconferencing are discussed. With illustrative examples, the author highlights the pathway to recovery for a wide range of clients with the comorbidity often found in real-world settings.  English | 2022 | ISBN: 0367197685 | 299 pages | True PDF | 18.68 MB The Sustainable Development Goals (SDGs) recognize the increasingly complex, interdependent nature of societal and environmental issues for governments and business. Tackling such "grand challenges" requires the concerted action of a multitude of organizations and multiple stakeholders at different levels in the public, private, and non-profit sector. Organizing for Sustainable Developmentprovides an integrated and comparative overview of the successes and failures of organizational efforts to tackle global societal issues and achieve sustainable development. Summarizing years of study by an interdisciplinary board of authors and contributors, this book provides readers with an in-depth understanding of how existing businesses and new hybrid organizations can achieve sustainable development to bring about an improved society, marking a key contribution to the literature in this field.  English | 2022 | ISBN: 3030847055 | 365 pages | True PDF EPUB | 8.27 MB This edited collection casts light on central issues within contemporary philosophy of mathematics such as the realism/anti-realism dispute; the relationship between logic and metaphysics; and the question of whether mathematics is a science of objects or structures. The discussions offered in the papers involve an in-depth investigation of, among other things, the notions of mathematical truth, proof, and grounding; and, often, a special emphasis is placed on considerations relating to mathematical practice.  English | 2022 | ISBN: 303054351X | 466 pages | True PDF EPUB | 26.47 MB This book presents Special Relativity in a language accessible to students while avoiding the burdens of geometry, tensor calculus, space-time symmetries, and the introduction of four vectors. The search for clarity in the fundamental questions about Relativity, the discussion of historical developments before and after 1905, the strong connection to current research topics, many solved examples and problems, and illustrations of the material in colloquial discussions are the most significant and original assets of this book. Importantly for first-time students, Special Relativity is presented such that nothing needs to be called paradoxical or apparent; everything is explained. The content of this volume develops and builds on the bookRelativity Matters(Springer, 2017). However, this presentation of Special Relativity does not require 4-vector tools. The relevant material has been extended and reformulated, with additional examples and clarifications. |
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