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![]() Free Download Dysfunction and Deviance Across Family Firms: Varying Reflections of the Dark Side by Roland E. Kidwell English | 2024 | ISBN: 3031518152 | 148 Pages | True PDF | 2.5 MB ![]() Free Download Henk A. Dijkstra, "Dynamical Oceanography" English | 2008 | pages: 408 | ISBN: 3540763759, 3642095259 | PDF | 13,8 mb This textbook provides a mathematical introduction to the theory of large-scale ocean circulation. It is accessible for readers with an elementary knowledge of mathematics and physics, including continuum mechanics and solution methods for ordinary differential equations. ![]() Free Download Dynamic Systems Development Method: Comprehensive Guide to Agile Project Success by Daniel Green English | March 17, 2024 | ASIN: B0CYBFML45 | 132 pages | PNG (.rar) | 20 Mb ![]() Free Download Dynamic Behavior of Materials, Volume 1 English | 2024 | ISBN: 3031506456 | 140 Pages | PDF EPUB (True) | 63 MB Dynamic Behavior of Materials, Volume 1 of the Proceedings of the 2023 SEM Annual Conference & Exposition on Experimental and Applied Mechanics, the first volume of seven from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on fundamental and applied aspects of Experimental Mechanics, including papers on: ![]() Free Download Rajesh Srivastava, "Dyke Swarms: Keys for Geodynamic Interpretation" English | 2011 | pages: 611 | ISBN: 364212495X, 3642444350 | PDF | 29,1 mb Dykes occur in a wide variety of geological and tectonic settings and their detailed study through space and time is imperative for understanding several geological events. Dykes are believed to be an integral part of continental rifting and when they occur as spatially extensive swarms of adequate size, they can be of immense utility in continental reconstructions and also help to identify Large Igneous Provinces (LIPs). It is known that continental flood basalts and major dyke swarms have their origin related in some way to the up-rise of hot mantle plumes which may lead to rifting and eventual continental break-up. Dykes signify crustal extension and are important indicators of crustal stabilisation events, supercontinental assembly and dispersal, crust-mantle interaction and play a significant role in the delineation of crustal provinces as well as in deciphering crustal evolution events. Many economic mineral deposits of the world are also associated with a variety of dykes. The volume will provide state-of-the-art information on all aspects of dykes with emphasis on the origin, evolution and emplacement of dykes. ![]() Free Download Elaine Kelly, "Dwelling in the Age of Climate Change: The Ethics of Adaptation" English | ISBN: 1474422969 | 2018 | 224 pages | EPUB | 290 KB Currently, adaptation policy for climate change prioritises economic and technological dimensions of governance and action. Now, Elaine Kelly brings continental theory into the conversation to explore the ethical dilemmas stemming from emerging global political crises of migration, displacement and communal relocation related to climate change. She argues that, in the era of anthropocentric climate change, an 'ethos of dwelling' must underpin adaptation practices. ![]() Free Download Kieran Allen, "Durkheim: A Critical Introduction" English | ISBN: 0745337406 | 2017 | 224 pages | EPUB | 352 KB Emile Durkheim, along with Karl Marx and Max Weber, is one of the three 'founding fathers of sociology'. This is the first book to situate his sociology in the context of his republican politics, freeing his ideas from more conventional studies and allowing the reader to see his ideas afresh. This critical introduction argues that Durkheim's defence of Republican France in the 1890s had a considerable influence on his sociology, which cannot be fully understood when removed from its historical and political context. His dismissal of economic factors in suicide rates, the influence of his anti-feminist position on his findings on marriage rates, and the idealism behind his claim that religion is the key determinant in shaping society are all discussed. Through analysing his writings, including The Division of Labour in Society, Suicide and The Elementary Forms of Religious Life, this book provides a fascinating, critical counterpoint to the existing works on this key figure of sociology. ![]() Free Download Kelly Chibale, Mike Davies-Coleman, Collen Masimirembwa, "Drug Discovery in Africa: Impacts of Genomics, Natural Products, Traditional Medicines, Insights into Medicinal Chemistry, and Technology Platforms in Pursuit of New Drugs" English | 2012 | pages: 453 | ISBN: 3642281745, 3642430228 | PDF | 8,7 mb Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa. Compiled by leading African and international experts, this book presents the science and strategies of modern drug discovery. It explores how the use of natural products and traditional medicines can benefit from conventional drug discovery approaches, and proposes solutions to current technological, infrastructural, human resources, and economic challenges, which are presented when attempting to engage in full-scale drug discovery. Topics addressed are varied; from African medicinal plants to marine bioprospecting, pharmacogenetics and the use of nanotechnology. This book brings together for the first time a collection of strategies and techniques that need to be considered when developing drugs in an African setting. 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These tests were followed by pharmacokinetic studies, which were mainly aimed at confirming of a suitable half-life time and at oral activity. Safety aspects relied mostly on toxicity studies, which however gave information on changes of organ structure rather than on organ function. Toxicological and pharmacokinetic studies were adapted to the progress of studies in clinical pharmacology and clinical trails. This "sequential" strategy has been abandoned for several reasons: - Some negative effects on organ function, e.g. ventricular tachy-arrhythmia, were detected too late. On the other hand, negative findings in chronic toxicity studies in animals turned out to be irrelevant for human beings.- New scientific approaches, e.g. combinatorial chemistry, high-throughput screening, in silico models, pharmaco-genomics and pharmaco-proteomics offered new possibilities.- There are several examples which show that the "druggability" of compounds was considerably underestimated when the probability of success of a new project was assessed.The success rate in the pharmaceutical industry and the introduction of new chemical entities to the market per year dropped dramatically, whereas the development time for a new compound increased, sometimes exceeding the patent protection. A change of strategy was therefore adopted, involving the following changes: - Parallel instead of sequential involvement of the various disciplines (multidimensional compound optimization).- The term "Safety Pharmacology" was coined. The International Conference on Harmonization (ICH) founded a Safety Pharmacology Working Group. Easily accessible and the most informative tests now have to be selected.- Exposure of a drug to the body by pharmacokinetic studies on absorption, distribution, metabolism and excretion has to be investigated at an early stage of development and can contribute to the selection of a compound for development. Toxicology experienced major achievements by the introduction of new methods, e.g., in silico methods, toxicogenomics and toxicoproteomics.The book is a landmark in the continuously changing world of drugs. As such it is important reading for many groups: not only for all students of pharmacology and toxicology but also for physicians, especially those involved in clinical trials of drugs, and for pharmacists who have to know the safety requirements of drugs.The book is absolutely essential for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process.In particular, the book will be of use for government institutions and committees working on official guidelines for drug evaluation worldwide. ![]() Free Download Driving Smart Medical Diagnosis Through AI-Powered Technologies and Applications Alex Khang English | 2024 | ISBN: 9798369336793 | 333 Pages | True ePUB / pdf | 21 MB |