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 Free Download The Oncogenomics Handbook By Xuefeng Bruce Ling PhD, Gene Cutler PhD, Timothy Hoey PhD (auth.), William J. LaRochelle PhD, Richard A. Shimkets PhD (eds.) 2005 | 750 Pages | ISBN: 1588294250 | PDF | 17 MB Bioinformatic integration of the findings from recent genomic and proteomic research has made possible the development of highly selective therapeutics that can target specific cellular pathways controlling cell proliferation, differentiation, metastasis, evasion of immune surveillance, angiogenesis, and apoptosis. In The Oncogenomics Handbook, a panel of internationally recognized researchers and clinicians provides an integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following that path, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including rituximab, Herceptin®, Avastin™, ABGX-EGF, Velcade®, Iressa®, and Zevalin® are addressed. Additional chapters review clinical diagnostics, bioanalytics, and biomarkers and their importance to therapeutic outcome; detail antiangiogenic, supportive, immunomodulatory, and tumor-targeted approaches to cancer therapy; and provide a systems biology-bioinformatics overview of strategies and initiatives for the postgenomic era. Highlights include cancer genomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation. Authoritative and state-of-the-art, The Oncogenomics Handbook offers cancer researchers and drug developers a comprehensive update on the contribution of the genomic revolution to cancer drug discovery and development.
 Free Download Daniel Amen MD, "The Omni Diet: The Revolutionary 70% PLANT + 30% PROTEIN Program to Lose Weight, Reverse Disease, Fight Inflammation, and Change Your Life Forever" English | 2013 | pages: 416 | ISBN: 1250029848, 1250029856, 1250031796 | EPUB | 4,5 mb By the time she had reached her mid-30s, Tana Amen had nearly given up on good health. Through a lifetime of chronic medical ailments, including severe digestive issues, recurrent infections and, most devastatingly, a battle with thyroid cancer, there was never a point when Tana felt consistently healthy. Doctors ascribed her poor health to genetics, bad luck, and a family history of obesity and heart disease. But even when Tana committed to a standard fitness and eating regimen, her health failed to improve.That's when she realized that she needed to make a real change. She needed to figure out how to improve her health . . . for good.  Free Download The Official Patient's Sourcebook on Smell and Taste Disorders By James N. Parker, Philip M. Parker 2002 | 120 Pages | ISBN: 0597831920 | PDF | 4 MB This book has been created for patients who have decided to make education and research an integral part of the treatment process. Although it also gives information useful to doctors, caregivers and other health professionals, it tells patients where and how to look for information covering virtually all topics related to smell and taste disorders (also ageusia; anosmia; hypogeusia; Hypogonadotropic Hypogonadism and Anosmia; hyposmia), from the essentials to the most advanced areas of research. The title of this book includes the word official. This reflects the fact that the sourcebook draws from public, academic, government, and peer-reviewed research. Selected readings from various agencies are reproduced to give you some of the latest official information available to date on smell and taste disorders. Given patients' increasing sophistication in using the Internet, abundant references to reliable Internet-based resources are provided throughout this sourcebook. Where possible, guidance is provided on how to obtain free-of-charge, primary research results as well as more detailed information via the Internet. E-book and electronic versions of this sourcebook are fully interactive with each of the Internet sites mentioned (clicking on a hyperlink automatically opens your browser to the site indicated). Hard-copy users of this sourcebook can type cited Web addresses directly into their browsers to obtain access to the corresponding sites. In addition to extensive references accessible via the Internet, chapters include glossaries of technical or uncommon terms.  Free Download The Official Patient's Sourcebook on Restless Leg Syndrome By James N. Parker, Philip M. Parker 2002 | 140 Pages | ISBN: 0597831831 | PDF | 4 MB This book has been created for patients who have decided to make education and research an integral part of the treatment process. Although it also gives information useful to doctors, caregivers and other health professionals, it tells patients where and how to look for information covering virtually all topics related to restless leg syndrome (also anxietas tibialis; crazy legs; Ekbom syndrome; hereditary acromelalgia; nocturnal myoclonus; Wittmaack-Ekbom syndrome), from the essentials to the most advanced areas of research. The title of this book includes the word official. This reflects the fact that the sourcebook draws from public, academic, government, and peer-reviewed research. Selected readings from various agencies are reproduced to give you some of the latest official information available to date on restless leg syndrome. Given patients' increasing sophistication in using the Internet, abundant references to reliable Internet-based resources are provided throughout this sourcebook. Where possible, guidance is provided on how to obtain free-of-charge, primary research results as well as more detailed information via the Internet. E-book and electronic versions of this sourcebook are fully interactive with each of the Internet sites mentioned (clicking on a hyperlink automatically opens your browser to the site indicated). Hard-copy users of this sourcebook can type cited Web addresses directly into their browsers to obtain access to the corresponding sites. In addition to extensive references accessible via the Internet, chapters include glossaries of technical or uncommon terms.
 Free Download The Official Patient's Sourcebook on Myeloproliferative Disorders: A Revised and Updated Directory for the Internet Age By Icon Health Publications 2002 | 252 Pages | ISBN: 0597834660 | PDF | 4 MB This sourcebook has been created for patients who have decided to make education and Internet-based research an integral part of the treatment process. Although it gives information useful to doctors, caregivers and other health professionals, it also tells patients where and how to look for information covering virtually all topics related to myeloproliferative disorders, from the essentials to the most advanced areas of research. The title of this book includes the word official. This reflects the fact that the sourcebook draws from public, academic, government, and peer-reviewed research. Selected readings from various agencies are reproduced to give you some of the latest official information available to date on myeloproliferative disorders. Following an introductory chapter, the sourcebook is organized into three parts. PART I: THE ESSENTIALS; Chapter 1. The Essentials on Myeloproliferative Disorders: Guidelines; Chapter 2. Seeking Guidance; Chapter 3. Clinical Trials and Myeloproliferative Disorders; PART II: ADDITIONAL RESOURCES AND ADVANCED MATERIAL; Chapter 4. Studies on Myeloproliferative Disorders; Chapter 5. Books on Myeloproliferative Disorders; Chapter 6. Physician Guidelines and Databases; Chapter 7. Dissertations on Myeloproliferative Disorders; PART III. APPENDICES; Appendix A. Researching Your Medications; Appendix B. Researching Alternative Medicine; Appendix C. Researching Nutrition; Appendix D. Finding Medical Libraries; Appendix E. Your Rights and Insurance; ONLINE GLOSSARIES; MYELOPROLIFERATIVE DISORDERS GLOSSARY; INDEX. Related topics include: Myeloproliferative disease.  Free Download Judith A. Siess, "The OPL Sourcebook : A Guide for Solo and Small Libraries" English | 2001 | pages: 401 | ISBN: 1573871117 | PDF | 1,4 mb Judith A. Siess, author of "The Solo Librarian's Sourcebook (1997) and editor of the monthly newsletter "The One-Person Library, has created the definitive handbook and directory for small and one-person libraries (OPLs). The book includes useful tips, case studies, and strategies to help OPLs survive and thrive in a digitized (and downsized) future. "The OPL Sourcebook also includes a comprehensive directory to important organizations, publications, vendors and suppliers, discussion lists, and Web sites.  Free Download Philip Henshall - The Nuclear Axis: Germany, Japan and the Atom Bomb Race 1939-45 Sutton Publishing | 2000 | ISBN: 0750922931 | English | 264 pages | PDF | 161.51 MB It has been generally accepted that Germany and Japan were years behind the Allies in producing a nuclear weapon during World War II and that Japan in particular was technically incapable of doing so. The author argues that these assumptions are unfounded and reveals that an Axis nuclear weapon was a very real threat to the Allies. Philip Henshall begins by outlining how Germany's conventional military situation began to deteriorate from 1943 onwards, how interest was revived in secret long-range weapons, and how SS General Kammler assumed virtually complete control of all long-range weapons projects. The origin of weapons in Germany is examined, with parallel references to the USA's Manhattan Project and, Henshall puts forward his theory that the leading figure in German nuclear science, Heisenberg, knew what was required to build an atomic bomb and fully understood the physics of the device - contrary to the accepted version of events.  Free Download Daniel Boyarin, "The No-State Solution: A Jewish Manifesto" English | ISBN: 0300251289 | 2023 | 200 pages | PDF | 588 KB A provocative manifesto, arguing for a new understanding of the Jews' peoplehood
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 Free Download The Night Lives On: The Untold Stories & Secrets Behind the Sinking of the Unsinkable Ship-Titanic By Walter J. Lord 1998 | 244 Pages | ISBN: 0380732033 | EPUB | 1 MB The most awesome ocean-going vessel the world had ever seen, the mightly TITANIC struck an iceberg and sank on the night of April 14, 1912, carrying more than 1500 souls--and uncountable secrets--to the icy bottom of the mid-Atlantic. Why did the crew steam full speed ahead into dangerous waters despite six wireless warnings? How able was the doomed behemoth.s .superb seaman. Captain Smith? Why did the nearby ship Californian ignore Titanic.s distress signals? How could such a disaster ever have occurred?Author Walter Lord.s acclaimed classic A Night to Remember is considered the definitive written work on the TITANIC tragedy. And now he returns to the scene of chaos and horror to explore--and answer--the untold mysteries behind the twentieth century.s greatest catastrophe at sea. |
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