Free Download Phosphoinositide 3-kinase in Health and Disease: Volume 1 By Tina L. Yuan, Lewis C. Cantley (auth.), Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt (eds.) 2011 | 310 Pages | ISBN: 3642136621 | PDF | 5 MB From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here the authors give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here. 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Theologically, the historicity of Adam and Eve speaks to original sin, redemption, and God's plan and purpose for humanity. Free Download Perspectives on Teaching and Learning English Literacy in China By Ran Hu, Bob Adamson (auth.), Jiening Ruan, Cynthia B. Leung (eds.) 2012 | 168 Pages | ISBN: 9400749937 | PDF | 2 MB This is one of two volumes by the same editors that explore historical, philosophical, and cultural perspectives on literacy in China. This volume focuses on English literacy in China, while the other volume is on Chinese literacy. In modern day China, English has enjoyed an increasingly important status in education, but not without challenges. The essays in this volume provide a comprehensive, cross-disciplinary look at changes in English literacy practices and literacy instruction in China from the first English school in the 19th century to recent curriculum reform efforts to modernize English instruction from basic education through higher education. Together, the essays address a wide array of topics, including early childhood English education, uses of information technology to teach English, and teaching English to Chinese minority students. This work is essential reading for those who want to expand their understanding of English literacy education in China. Free Download Perspectives on Teaching and Learning Chinese Literacy in China By Liqing Tao, Gaoyin Qian (auth.), Cynthia B. Leung, Jiening Ruan (eds.) 2012 | 222 Pages | ISBN: 9400748213 | PDF | 3 MB This is one of two volumes by the same editors that explore historical, philosophical, and cultural perspectives on literacy in China. This volume focuses on Chinese literacy, while the other volume is on English literacy. Since the founding of the People's Republic of China, the country has witnessed a dramatic increase in its literacy rate, but not without challenges. The essays in this volume provide a comprehensive, cross-disciplinary look at changes in Chinese literacy education from ancient times to the modern day. Together, the essays address a wide array of topics, including early Chinese literacy development, children's literature, foreign translated literature, and uses of information technology to teach Chinese. This authoritative text brings clarity and precision to the field and serves as a vital core resource for those who want to expand their understanding of Chinese literacy education. Its scope is unmatched even in academic literature in the Chinese language. Free Download Crawford Howie, Paul Hawkshaw, Timothy Jackson, "Perspectives on Anton Bruckner" English | 2017 | ISBN: 1138263346, 0754601102 | PDF | pages: 449 | 122.7 mb A century after his death Anton Bruckner still remains one of the most complex and enigmatic creative personalities of the nineteenth century. A leading avant-garde figure of his generation, he was an accomplished performer and teacher in addition to being a great composer; few people in the history of western music can boast his level of achievement in all these areas combined. This book, a collection of essays written by an international group of scholars, offers diverse theoretical and musicological perspectives on Bruckner the composer-teacher-performer. Facets of his formidable theoretical training and his application of it as part of the compositional process are explored. A variety of analytical methodologies is used to examine the Second through to the Ninth Symphonies, the heart of the composer's mature repertoire. Finally, aspects of Bruckner's career as a teacher and performer, his complex personality, his influence and dissemination of his music are considered.
Free Download People on the Move in a Changing Climate: The Regional Impact of Environmental Change on Migration By Frank Laczko, Etienne Piguet (auth.), Etienne Piguet, Frank Laczko (eds.) 2014 | 253 Pages | ISBN: 9400769849 | PDF | 4 MB Policymakers around the world are increasingly concerned about the likely impact of climate change and environmental degradation on the movement of people. This book takes a hard look at the existing evidence available to policymakers in different regions of the world. How much do we really know about the impact of environmental change on migration? How will different regions of the world be affected in the future? Is there evidence to show that migration can help countries adapt to environmental change ? What types of research have been conducted, how reliable is the evidence? These are some of the questions considered in this book, which presents, for the first time, a synthesis of relevant research findings for each major region of the world.Written by regional experts, the book provides a comprehensive overview of the key findings of existing studies on the linkages between environmental change and the movement of people. More and more reports on migration and the environment are being published, but the information is often scattered between countries and within regions, and it is not always clear how much of this information is based on solid research. This book brings this evidence together for the first time, highlighting innovative studies and research gaps. In doing this, the book seeks to help decision-makers draw lessons from existing studies and to identify priorities for further research. Free Download Peeing and Pooping in Space: A 100% Factual Illustrated History by Kiona N. Smith English | May 21, 2024 | ISBN: 0762486619 | 112 pages | MOBI | 31 Mb Explore the irreverent side of space travel-and learn about the marvels of modern engineering-in this hilarious illustrated guide to excrement etiquette in the midst of adventurous endeavors. Free Download Pediatric Cancer, Volume 3: Diagnosis, Therapy, and Prognosis By Christine Haberler, Irene Slavc (auth.), M.A. Hayat (eds.) 2012 | 301 Pages | ISBN: 9400745273 | PDF | 6 MB Brain tumors are the most common solid tumor of childhood as well as the leading cause of cancer-related mortality in children. This third volume of the Springer series discussing pediatric cancer focuses on diagnosing, treating, and assessing the future course of malignant brain neoplasms in children. In addition to a general introduction to the principals involved, the material includes vital research in molecular genetics, a major contribution to the molecular characterization of solid tumors, which will define new biomarkers of the disease and identify molecular pathways. Now it has become possible to achieve the goal of targeting new, more effective therapies to minimize the tragedy faced by children. This research features the application of molecular genetics in combating atypical teratoid/rhabdoid tumor (AT/RT), a highly aggressive embryonal CNS tumor that is among the most common malignant neoplasms in children, with a peak occurrence in infants younger than three years old. Contributors also examine the reasons for the common misdiagnosis of AT/RT tumors as other types of CNS tumors. They help resolve this issue by indicating the details of an abnormality in the genetics of AT/RT, which is unique to AT/RT type. The INII gene on chromosome 22q11 is involved in the AT/RT. The presence of this gene and the SMARCB1 is discussed. In addition to discussing these important topics, the volume includes presentations of present and future therapies. The volume also explains AT/RT's dissemination to the cerebral fluid, the molecular mechanisms underlying the progression of medulloblastoma, and the importance of gamma knife radiosurgery during multimodality management of medulloblastoma/PNET tumors. Other topics discussed include using magnetic resonance imaging for diagnosing retinoblastoma, and mapping the effects of radiotherapy in low-grade glioma in children. Information on alterations in cell-cycle regulators that are influenced by tumor suppressor genes and oncogenes is detailed. Contributors provide recommendations concerning non-narcotic analgesic routines for children recovering from cranial and spinal surgery. The practical knowledge of frontier-expanding research presented leads this authoritative volume to be a compelling addition to the literature. |