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Free Download Pediatric Endocrinology: A Practical Clinical Guide, Second Edition By Christopher J. Romero M.D., Andrew N. Dauber M.D., Laurie E. Cohen M.D. (auth.), Sally Radovick, Margaret H. MacGillivray (eds.) 2013 | 624 Pages | ISBN: 1607613948 | PDF | 12 MB A state-of-the-art and concise guide to the clinical management of pediatric endocrine disorders, the second edition of the highly regarded Pediatric Endocrinology: A Practical Clinical Guide covers the most common and challenging conditions seen by practicing endocrinologists and primary care physicians, including growth, hypothalamic, pituitary, adrenal, thyroid, calcium and bone, and reproductive disorders, as well as metabolic syndromes. This expanded second edition includes new topics being seen more commonly in pediatric endocrinology practices related to obesity and type 2 diabetes mellitus and lipid disorders. Each chapter contains an introductory discussion of the problem, a review of the clinical features that characterize it, the criteria needed to establish a diagnosis, and a comprehensive therapy section delineating the risks and benefits of the best therapeutic options available. Invaluable tables summarize the critical factors in etiology, clinical presentation, diagnosis, and therapeutic dosages. Pediatric Endocrinology: A Practical Clinical Guide, Second Edition, is a comprehensive resource for all clinicians concerned with the myriad endocrinologic disorders seen in children and adolescents. Free Download Myŏngik Ch'oe, "Patterns of the Heart and Other Stories " English | ISBN: 0231202709 | 2024 | 304 pages | PDF | 2 MB Korean writer Ch'oe Myŏngik was a lifelong resident of Pyongyang, a city his short stories masterfully evoke in exquisite modernist prose. His career spanned decades of tumult, from his debut in the 1930s while Korea was under Japanese colonial rule through the Asia-Pacific and Korean Wars and the early years of the Democratic People's Republic. As Pyongyang transformed from Korea's second city, peripheral to the Seoul-centered literary scene, into a socialist capital in the late 1940s, Ch'oe briefly ascended to the center of North Korean culture. Despite the vitality and originality of Ch'oe's writing, Cold War politics and censorship, including South Korea's anticommunist laws, consigned his work to obscurity. Free Download Pathology of the Pancreas: A Practical Approach by Fiona Campbell English | EPUB | 2021 | 438 Pages | ISBN : 3030498476 | 843.9 MB This updated volume provides a practical guide to pancreatic pathology that covers recent changes in concepts and classifications. Potential pitfalls and mimics in pancreatic pathology are highlighted and illustrated, and guidance is provided regarding how to recognise and avoid them. There is a new chapter on transplant pathology, and more than 200 new macroscopic and microscopic images have been added. Free Download Patho-Epigenetics of Disease By Walter Doerfler MD (auth.), Janos Minarovits, Hans Helmut Niller (eds.) 2012 | 466 Pages | ISBN: 1461433444 | PDF | 5 MB In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences.Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to "remember" their proper cellular identity. An alternative system of epigenetic memory, the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression via modification of histone tails. The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transmission of gene expression patterns to each progeny cell upon division. These carefully orchestrated processes can go wrong, however, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes, as it was first realized during the studies of epigenetic alterations in malignant tumors. By now it became a well established fact that not only genetic changes, but also the disruption of epigenetic regulation can result in carcinogenesis and tumor progression. Scientists working in other fields soon followed the pioneering work of cancer researchers, and revealed that epigenetic dysregulation forms the basis of a wide spectrum of human diseases. 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It supports the teaching of reading and spelling through synthetic phonics. Supported by the Floppy's Phonics Sounds and Letters Programme, it follows the Alphabetic Code Chart showing the sounds and alternative spellings that children will need to learn to become proficient readers and spellers. The words are ordered by initial sound and there are subsections to show how the same sounds appear in the middle or at the end of a word. The long vowel sounds and their alternative spellings appear in a separate section within the dictionary. This unique dictionary makes it easy to explain how 'sun' and 'Cinderella' both start with the 's' sound and how 'dance' has the same 's' sound at the end, while 'egg' and 'eat' start with the same letter but different sounds. With colourful illustrations by Alex Brychta and the familiar Oxford Reading Tree characters, this is a fun way to prepare for the phonics screening check. There is additional phonics support material and audio on the Oxford Owl website,http://www.oxfordowl.co.uk. For more free downloadable word games, puzzles, and activities go online towww.oxforddictionaries.com/schools. |