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 Free Download Nucleic Acid Drugs By Junichi Yano, Gerald E. Smyth (auth.), Akira Murakami (eds.) 2012 | 180 Pages | ISBN: 3642304621 | PDF | 4 MB New Antisense Strategies: Chemical Synthesis of RNA Oligomers, by Junichi Yano und Gerald E. Smyth Development and Modification of Decoy Oligodeoxynucleotides for Clinical Application, by Mariana Kiomy Osako, Hironori Nakagami und Ryuichi Morishita Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides, by Ekambar R. Kandimalla und Sudhir Agrawal Delivery of Nucleic Acid Drugs, by Yan Lee und Kazunori Kataoka Aptamer: Biology to Applications, by Yoshikazu Nakamura Development and Clinical Applications of Nucleic Acid Therapeutics, by Veenu Aishwarya, Anna Kalota und Alan M. Gewirtz  Free Download Nuclear Reprogramming and Stem Cells By John Gurdon, Azim Surani (auth.), Justin Ainscough, Shinya Yamanaka, Takashi Tada (eds.) 2012 | 332 Pages | ISBN: 1617792241 | PDF | 16 MB Research into the field of stem cell biology has developed exponentially over recent years, and is beginning to offer significant promise for unravelling the molecular basis of a multitude of disease states. Importantly, in addition to offering the opportunity to delve deeply into the mechanisms that drive disease aetiology the research is realistically opening the doors for development of targeted and personalized therapeutic applications that many considered, until recently, to be nothing more that a far fetched dream. This volume provides a timely glimpse into the methods that have been developed to instigate, and the mechanisms that have been identified to drive, the process of nuclear reprogramming, chronicling how the field has developed over the last 50-60 years.Since the early 1950s a small number of notable experiments have provided significant impetus to the field, primarily the demonstration of reprogramming ability, first by the complex cytoplasmic milieu that constitutes the amphibian egg, then that of the mammalian egg, and finally that of the mammalian embryonic stem cell. Most recently, the demonstration that a limited pool of defined molecules is capable of reprogramming a multitude of cell types has provided massive impetus and facilitated transition towards realistic therapeutic application. We have therefore reproduced some of the key articles that elegantly document these dramatic stages of development of the field in an inclusive appendix to the book, for the benefit of readers keen to investigate the history of how the field of stem cell biology has evolved. Owing to the ever broadening nature of this field, and the incredible rate at which it is evolving, the main content of this volume focuses on areas that have shown significant movement in recent years, are most likely to translate into personalized therapeutic application, and thus provide greatest potential for significant impact on human health in the not too distant future. We recognize that research into many other disease states and cell types are all equally worthy of discussion. We would therefore like to acknowledge those researchers involved whose work we have not been able to include in this volume. Nuclear Reprogramming and Stem Cells will serve as a valuable resource for all researchers in the field of stem cell biology, including those just setting out on their career path as well as those already established in the field.  Free Download PH D David E Newton, "Nuclear Power" English | 2006 | pages: 305 | ISBN: 0816056552 | PDF | 1,3 mb Outlines the history of nuclear power production in the United States and the issues that arise from the use of nuclear power in the production of energy. A single-volume reference, this book is for anyone interested in nuclear power, including policy-makers, attorneys, and advocacy groups, as well as teachers, students, and the general public.  Free Download Michael Gardiner, "Nuclear Fictions: Violence and the Narration of the Anglosphere" English | ISBN: 1474475728 | 2024 | 232 pages | PDF | 3 MB In this book, Michael Gardiner suggests that the conception of the 'war-ending' weapon was tied up with a longer commitment to unified space and singular progress. The mission for total weapons can be seen rising with the highly-technical defensive war of the later nineteenth century, and passing through twentieth century atomic research, then the targeting of the outsides of commercial empire, and the post-war consensus with deterrence as its foundation. The end of the Cold War brought an opportunity to fully naturalise deterrence, but also brought a tacit acceptance of nuclear violence while forms of violence against the individual were rigorously sought out. If the world-unifying role of deterrence has always been undermined by the rise of rival empires, it has also been questioned by critical communities including the consensus-sceptics of the 1950s-60s, 1980s-90s Nuclear Criticism and readers of 'nuclearism', millennial campaigns for Scottish independence, and twenty-first century descriptions of nuclear colonialism. Recently it has become more obvious that an Anglosphere concept of 'worldly' deterrence was bound to a singular and ultimately nihilistic idea of progress.ioMichael Gardiner is Professor in the Department of English and Comparative Literature at the University of Warwick.
 Free Download Nowhere to Run: The ridiculous life of a semi-professional football club chairman by Jonathan Sayer English | 10 Aug. 2023 | ISBN: 1787636895 | True EPUB | 256 pages | 1 MB On the second oldest football pitch in the world, Jonathan Sayer stands atop a beer crate to address the assembled fans of Ashton United FC. As his initial optimism begins to slip through his fingers, the new co-chairman and co-owner (alongside his dad) starts to realise the scale of the challenge ahead.  Free Download Novel Apoptotic Regulators in Carcinogenesis By Azman Seeni, Nur Ayunie Zulkepli (auth.), George G. Chen, Paul B.S. Lai (eds.) 2012 | 300 Pages | ISBN: 9400749163 | PDF | 5 MB Our recent understanding of the cellular and molecular defects and the regulation of the apoptotic signalling pathways has resulted in rationally designed anticancer strategies and the development of novel agents that regulates apoptosis. A comprehensive review of all apoptotic-related anticancer therapies is not the purpose of this book. However, in the volume of this book with 11 chapters, we have described a number of novel apoptotic regulators that have shown promising value and also great feasibility for cancer treatment. These novel agents either occur naturally or are chemically synthesized. While we are excited about the discovery and development of these novel apoptotic regulators as potential anticancer agents, a degree of caution should be always borne in mind when interpreting the success of preclinical pro-apoptotic candidates since potential problems inevitably lie ahead. These problems usually include target specificity, unanticipated toxicity, compound stability, formulation issues, pharmacokinetic and pharmacodynamic profiles. Nevertheless, we believe that this collection of 11 chapters by established leaders in the area of apoptosis will be of great interest to not only academics working in the field of cancer research and apoptosis but also pharmaceutical and pharmacological industries that . We are looking forward to the further development to push these potential agents toward clinical stage.  Free Download Notch Signaling in Embryology and Cancer By Sang-Mo Kwon, Cantas Alev, Sang-Hun Lee (auth.), Jörg Reichrath, Sandra Reichrath (eds.) 2012 | 322 Pages | ISBN: 1461408989 | PDF | 6 MB The goal of this volume is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer. Experts in the field as well as scientists and health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for every clinician or scientist interested in the role of Notch signalling in embryology and cancer. We hope that this volume will be adopted as the standard text in this area of science and will stimulate new interest in the role of Notch signalling for embryology and cancer. We further hope that this compendium will serve as both a source for current researchers and a guide to stimulate and assist those in related disciplines to enter this exciting field of research.
 Free Download North Korea Confidential: Private Markets, Fashion Trends, Prison Camps, Dissenters and Defectors, 2nd Edition by Daniel Tudor, James Pearson English | October 6, 2020 | ISBN: 080485226X | True EPUB | 232 pages | 12.7 MB What is life in North Korea really like?  Free Download Duncan Curtis - North American QF-86E/F/H Sabre Full Scale Aerial Targets (Naval Fighters 58) Ginter Books | 2001 | ISBN: 0942612582 | English | 84 pages | PDF | 262.42 MB This was one of the first aircraft used as a target drone. This book explains the original concept outlining the need for a remote controlled aircraft and how that concept evolved into the QF-86 program. Lots of photographs from both inside and outside the cockpit.  Free Download Nora Ephron at the Movies: A Visual Celebration of the Writer and Director Behind When Harry Met Sally, You've Got Mail, Sleepless in Seattle, and More by Ilana Kaplan and Jason Diamond English | 2024 | ISBN: 1419763636 | 224 Pages | True ePUB | 38 MB |
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