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Free Download Bioinformatics and Drug Discovery By Kubilay Demir, Michael Boutros (auth.), Richard S. Larson (eds.)
2012 | 374 Pages | ISBN: 1617799645 | PDF | 8 MB
Recent advances in drug discovery have been rapid. The second edition of Bioinformatics and Drug Discovery hasbeen completely updated to include topics that range from new technologies in target identification, genomic analysis, cheminformatics, protein analysis, and network or pathway analysis. Each chapter provides an extended introduction that describes the theory and application of the technology. In the second part of each chapter, detailed procedures related to the use of these technologies and software have been incorporated. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Bioinformatics and Drug Discovery, Second Edition seeks to aid scientists in the further study of the rapidly expanding field of drug discovery.

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Free Download Biodiversity and Evolutionary Ecology of Extinct Organisms By Rituparna Bose (auth.)
2013 | 102 Pages | ISBN: 3642317200 | PDF | 3 MB
Increasing rate of species extinction in the present day will lead to a huge biodiversity crisis; eventually, this will lead to the paucity of non-renewable resources of energy making our Earth unsustainable in future. To save our mother planet from this crisis, studies need to be performed to discover abundant new fossil sites on Earth for continued access to oil-rich locations. Most importantly, a holistic approach is necessary in solving the present problem of biodiversity loss. This book presents newly developed quantitative models in understanding the biodiversity, evolution and ecology of extinct organisms. This will assist future earth scientists in understanding the natural and anthropogenic causes behind biodiversity crisis and ecosystem collapse. In addition, this study would be of great interest to exploration geologists and geophysicists in potentially unraveling natural resources from our sustainable Earth.

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Free Download Biodiversitat und Klimawandel: Auswirkungen und Handlungsoptionen fur den Naturschutz in Mitteleuropa By Dr. M. Croci-Maspoli, PD Dr. F. Essl (auth.), Franz Essl, Wolfgang Rabitsch (eds.)
2013 | 458 Pages | ISBN: 3642296912 | PDF | 30 MB
Das Buch „Biodiversität und Klimawandel" bietet einen zusammenfassenden Überblick der Klimawandeleffekte für die Biodiversität in Mitteleuropa. Dabei nimmt die Bewertung der beobachteten und prognostizierten Folgen des Klimawandels auf Arten und Lebensräume und die Ableitung von Handlungsoptionen unter der Leitlinie des frühzeitigen Handelns und der Risikovorsorge einen zentralen Raum ein. Es werden auch Querverbindungen zu menschlichen Aktivitäten wie Land- und Forstwirtschaft, Jagd und Fischerei gezogen und die Implikationen für die Gesundheitsvorsorge dargestellt. Besonderer Stellenwert wird Wechselwirkungen mit anderen Elementen des Global Change wie Biologischen Invasionen und Landnutzungswandel eingeräumt. Ergebnisse von Fallstudien werden zur anschaulichen Darstellung der Zusammenhänge präsentiert.

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Free Download Biocommunication of Plants By Witzany Guenther (auth.), Günther Witzany, František Baluška (eds.)
2012 | 386 Pages | ISBN: 3642235239 | PDF | 4 MB
Plants are sessile, highly sensitive organisms that actively compete for environmental resources both above and below the ground. They assess their surroundings, estimate how much energy they need for particular goals, and then realise the optimum variant. They take measures to control certain environmental resources. They perceive themselves and can distinguish between 'self' and 'non-self'. They process and evaluate information and then modify their behaviour accordingly. These highly diverse competences are made possible by parallel sign(alling)-mediated communication processes within the plant body (intraorganismic), between the same, related and different species (interorganismic), and between plants and non-plant organisms (transorganismic). Intraorganismic communication involves sign-mediated interactions within cells (intracellular) and between cells (intercellular). This is crucial in coordinating growth and development, shape and dynamics. Such communication must function both on the local level and between widely separated plant parts. This allows plants to coordinate appropriate response behaviours in a differentiated manner, depending on their current developmental status and physiological influences. Lastly, this volume documents how plant ecosphere inhabitants communicate with each other to coordinate their behavioural patterns, as well as the role of viruses in these highly dynamic interactional networks.

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Free Download Biocommunication of Fungi By Guenther Witzany (auth.), Günther Witzany (eds.)
2012 | 344 Pages | ISBN: 9400742630 | PDF | 5 MB
Fungi are sessile, highly sensitive organisms that actively compete for environmental resources both above and below the ground. They assess their surroundings, estimate how much energy they need for particular goals, and then realise the optimum variant. They take measures to control certain environmental resources. They perceive themselves and can distinguish between 'self' and 'non-self'. They process and evaluate information and then modify their behaviour accordingly. These highly diverse competences show us that this is possible owing to sign(aling)-mediated communication processes within fungal cells (intraorganismic), between the same, related and different fungal species (interorganismic), and between fungi and non-fungal organisms (transorganismic). Intraorganismic communication involves sign-mediated interactions within cells (intracellular) and between cells (intercellular). This is crucial in coordinating growth and development, shape and dynamics. Such communication must function both on the local level and between widely separated mycelium parts. This allows fungi to coordinate appropriate response behaviors in a differentiated manner to their current developmental status and physiological influences.

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Free Download Biocommunication in Soil Microorganisms By Guenther Witzany (auth.), Günther Witzany (eds.)
2011 | 476 Pages | ISBN: 3642145116 | PDF | 8 MB
Communication is defined as an interaction between at least two living agents which share a repertoire of signs. These are combined according to syntactic, semantic and context-dependent, pragmatic rules in order to coordinate behavior. This volume deals with the important roles of soil bacteria in parasitic and symbiotic interactions with viruses, plants, animals and fungi. Starting with a general overview of the key levels of communication between bacteria, further reviews examine the various aspects of intracellular as well as intercellular biocommunication between soil microorganisms. This includes the various levels of biocommunication between phages and bacteria, between soil algae and bacteria, and between bacteria, fungi and plants in the rhizosphere, the role of plasmids and transposons, horizontal gene transfer, quorum sensing and quorum quenching, bacterial-host cohabitation, phage-mediated genetic exchange and soil viral ecology.

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Free Download Biochemical Roles of Eukaryotic Cell Surface Macromolecules: 2011 ISCSM Proceedings By Garima Gupta, Avadhesha Surolia (auth.), Perumana R. Sudhakaran, Avadhesha Surolia (eds.)
2012 | 340 Pages | ISBN: 1461433800 | PDF | 9 MB
Cell surface molecules are critically important in regulating cell structure and function. Recent advances on the functional role of cell surface molecules, particularly glycoconjugates are presented in this book. Comprising of 22 chapters from the 2011 International Symposium on Biochemical Roles of Eukaryotic Cell Surface Macromolecules, it covers topics on the analysis of glycome, biophysical approaches to study cell surface molecules, glycoconjugate metabolism and its dysregulation, and molecular mechanisms involved in cell-cell and cell-matrix interaction.

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Free Download Bioactive Polyphenols from Wine Grapes By Jeffrey A Stuart, Ellen L Robb (auth.)
2013 | 66 Pages | ISBN: 1461469678 | PDF | 4 MB
Is red wine good for you? And if so, why? How much? And what are the actual benefits? This addition to the SpringerBriefs in Cell Biology series thoroughly but succinctly answers these questions. It covers the biochemistry, health benefits and therapeutic potential of wine grapes. It begins with an overview of phytoalexin production in Vitis vinifera (Common Grape Vine), detailing the relationship of resveratrol to analogues such as pterostilbene, piceid and the viniferins (resveratrol oligomers). The discussion then turns to the hundreds of reports linking resveratrol and related grape vine polyphenols to various beneficial health effects especially cardio- and cerebro- vascular, metabolic, anti-inflammatory and more. Also addressed are the numerous intracellular mechanisms that have been shown to mediate the effects of these compounds in mammalian cells and tissues. Finally, the authors discuss aspects of polyphenol bioavailability and how this will influence choices taken for delivering these compounds as nutritional supplements. A brief chapter containing general conclusions and prospectus rounds out the information. ​

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Free Download Dr. J. Normann Jørgensen, "Bilingualism and Social Relations: Turkish Speakers in North West Europe"
English | ISBN: 1853596507 | 2003 | 152 pages | PDF | 654 KB
Studies of the multilingual practices of Turkish speaking adolescents in North Western Europe. The speakers use their different languages for a wide range of purposes: getting their way, creating a comfortable atmosphere, saving face, being polite, showing respect, showing disrespect, scolding, and in many other ways to administer their social relations. The skills demonstrated by the young speakers are almost never taken into account by the majority societies.

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Free Download Annick De Houwer, "Bilingual First Language Acquisition "
English | ISBN: 184769148X | 2009 | 432 pages | PDF | 1424 KB
Increasingly, children grow up hearing two languages from birth. This comprehensive textbook explains how children learn to understand and speak those languages. It brings together both established knowledge and the latest findings about different areas of bilingual language development. It also includes new analyses of previously published materials. The book describes how bilingually raised children learn to understand and use sounds, words and sentences in two languages. A recurrent theme is the large degree of variation between bilingual children. This variation in how children develop bilingually reflects the variation in their language learning environments. Positive attitudes from the people in bilingual children''s language learning environments and their recognition that child bilingualism is not monolingualism-times-two are the main ingredients ensuring that children grow up to be happy and expert speakers of two languages.

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