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Free Download Reinforcement Learning for Finance: A Python-Based Introduction by Yves J. Hilpisch
English | November 19, 2024 | ISBN: 109816914X | True PDF | 212 pages | 10.7 MB
Reinforcement learning (RL) has led to several breakthroughs in AI. The use of the Q-learning (DQL) algorithm alone has helped people develop agents that play arcade games and board games at a superhuman level. More recently, RL, DQL, and similar methods have gained popularity in publications related to financial research.

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Free Download Regulatory RNAs in Prokaryotes By Professor Dr. Wolfgang R. Hess, Professor Dr. Anita Marchfelder (auth.)
2012 | 258 Pages | ISBN: 3709102170 | PDF | 6 MB
This book provides a comprehensive and up-to-date collection of review articles focusing on RNA-mediated regulation in prokaryotes. The various modes of action include the direct interaction with proteins, direct sensing of metabolites or of physical parameters, and the interaction with RNAs to stimulate or prevent binding of ribosomes or to stimulate degradation. Written by leading experts in the field, the book covers small RNA functions, RNA thermometers, riboswitches, the diversity of small RNA-guided CRISPR-Cas defense systems and selected RNA chaperons in both prokaryotic domains, bacteria and archaea. Recent advances towards the computational identification of regulatory RNAs and their targets are included and particular attention is paid to small RNA in pathogenic bacteria. This volume is the only one exclusively covering regulatory RNAs in the prokaryotic domains to date, making it essential literature for anyone interested in RNA function and gene regulation and a valuable resource for teaching these concepts.

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Free Download Regulatory RNAs: Basics, Methods and Applications By Zhumur Ghosh, Bibekanand Mallick (auth.), Bibekanand Mallick, Zhumur Ghosh (eds.)
2012 | 554 Pages | ISBN: 3642225160 | PDF | 8 MB
Recent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional levels rather than simply being an intermediated messenger between DNA and proteins. As the appreciation for the importance of ncRNAs continues to emerge, it is also increasingly clear that these play critical roles in gene regulatory processes during development and differentiation. Further, regulatory RNAs are useful biomarkers for diagnosis of diseases. Hence these RNA regulators are essential to the development of therapeutics. This book on "Regulatory RNAs" offers a comprehensive view on our current understanding of these regulatory RNAs viz. siRNA, miRNA, piRNA, snoRNA, long non-coding RNA, small RNA etc. It addresses both the biogenesis and mechanism of action of regulatory RNAs with a primary focus on their annotation, experimental methodologies (microarray, next-gen sequencing etc.) for their discovery, computational tools for their prediction, and above all, applications of these revolutionary regulatory molecules in understanding biological systems and diseases, including therapeutics. This comprehensive volume is intended for readers with research or teaching interests in ncRNA biology and will provide a major information resource on current research in the fast-moving fields of RNA and gene expression regulation. Cutting-edge and concise, "Regulatory RNAs: Basics, Methods and Applications" promises to support vital research in the field of regulatory RNAs, ever-continuing to grow rapidly and gain increasing importance in basic and translational biology.

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Free Download Regulatory Risk and the Cost of Capital: Determinants and Implications for Rate Regulation By Professor Dr. Burkhard Pedell (auth.)
2006 | 221 Pages | ISBN: 3540308016 | PDF | 3 MB
Austrian Controller Award 2005This book develops a comprehensive concept of regulatory risk integrating existing theoretical and empirical research. The focus is on explaining how the design of the regulatory system influences the risk of a rate-regulated firm, as well as on elaborating appropriate methods for the determination of the regulatory rate base and the allowed rate of return. Regarding the regulatory rate base, the question of whether market value of capital or book value of assets should be employed and the choice of the depreciation scheme are at the center of the discussion. Specific methodical issues concerning cost of capital assessment for rate-regulated firms are analyzed, i.e. the circularity of rate regulation, the sharing of risks between capital owners and rate payers, the length of the regulatory review period, the regulation of the capital structure as well as the conversion of a post-tax to pre-tax weighted average cost of capital.

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Free Download Regulation of Agricultural Biotechnology: The United States and Canada By Chris A. Wozniak Ph.D. (auth.), Chris A. Wozniak, Alan McHughen (eds.)
2012 | 396 Pages | ISBN: 9400721552 | PDF | 5 MB
Agricultural biotechnology takes many forms and applications, with the number and diversity of products ever increasing. With this rapid development, regulatory authorities have sought to keep pace through regulatory adjustments and advances to ensure the safe and beneficial use of this critical technology. The regulatory systems for the U.S. and Canada are not static and must evolve in order to maintain relevance, efficiency and applicability to the challenges encountered. The diverse authors, drawn from the biotechnology industry, academia, government research and regulatory agencies, offer their perspectives of the historical and current system and suggest where it can be improved in the future. Based upon vast experience interacting with the regulatory system, the editors and authors offer demystifying views of the US and Canadian regulatory structures and how they came to be. We know of no other effort to present the biotechnology regulatory systems of the US and Canada in an open forum which will benefit those in the regulated community as well as those charged with oversight of the products of biotechnology, and ultimately the consumer!

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Free Download Jason W. Osborne, "Regression & Linear Modeling: Best Practices and Modern Methods"
English | ISBN: 1506302769 | 2016 | 488 pages | EPUB | 19 MB
In a conversational tone, Regression & Linear Modeling provides conceptual, user-friendly coverage of the generalized linear model (GLM). Readers will become familiar with applications of ordinary least squares (OLS) regression, binary and multinomial logistic regression, ordinal regression, Poisson regression, and loglinear models. Author Jason W. Osborne returns to certain themes throughout the text, such as testing assumptions, examining data quality, and, where appropriate, nonlinear and non-additive effects modeled within different types of linear models.

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Free Download Peter Ainsworth, "Regions and Landscapes: Reality and Imagination in Late Medieval and Early Modern Europe"
English | ISBN: 3906765326 | 2001 | 244 pages | PDF | 12 MB
The present volume brings together European and American scholars from a range of complementary disciplines (cartographers, economic and social historians, historians of social and political institutions, economic geographers, historians of art and textual analysts), all of whom are interested in exploring potential interconnections between their respective approaches to the study of regions and landscapes, 'real' or imagined, in the early modern and medieval periods.

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Free Download Regionale Marken und Konsumentenverhalten: Konsequenzen für die Markenführung By Anja Geigenmüller (auth.)
2003 | 208 Pages | ISBN: 3824478978 | PDF | 11 MB
Mit der zunehmenden Globalisierung lassen sich verschiedene Strategien der Markenhersteller beobachten. Einerseits werden Markenportfolios stark reduziert bzw. Marken internationalisiert, andererseits akquirieren Unternehmen "regionale Schätze" und nehmen dabei sogar Kannibalisierungseffekte in Kauf. Anja Geigenmüller nutzt die Region der neuen deutschen Bundesländer, um den Einfluss der Markenherkunft auf die Wahrnehmung regionaler Marken zu untersuchen. Sie zeigt, dass regionale Marken an Marktbedeutung gewinnen und die Relevanz nationaler Marken in Frage stellen werden. Daraus leitet sie marken- und vor allem kommunikationspolitische Strategien zur Führung regionaler Marken in regionalen und überregionalen Märkten ab. Unter anderem wird dargestellt, welche strategische Rolle regionale Marken für internationale Markenunternehmen im Rahmen von Mehrmarkenstrategien spielen können und welche Konsequenzen damit verbunden sind. Die Erkenntnisse sind nicht nur für den deutsch-deutschen Markt, sondern auch für das Marketing im Rahmen der EU-Osterweiterung relevant.

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Free Download Regionale Innovationssysteme aus betriebswirtschaftlicher Perspektive: Gestaltungskonzepte zur Förderung einer nachhaltigen Unternehmensentwicklung By Wolfgang Gerstlberger (auth.)
2004 | 435 Pages | ISBN: 3824481758 | PDF | 11 MB
Um den Standort Deutschland ist eine äußerst kontrovers geführte Diskussion entbrannt. Für die einzelnen Regionen stellt sich dabei zunehmend die grundlegende Frage des Überlebens. Um die umfassende Entwicklung der Regionen und Unternehmen zu fördern, können Öffentliche Hand, Politik und Privatwirtschaft das Konzept der Regionalen Innovationssysteme (RIS) nutzen. Es umfasst verschiedene Formen der Kooperation zwischen unterschiedlichen Akteuren sowie quantifizierbare und nicht-monetarisierbare Kriterien dafür. Wolfgang Gerstlberger untersucht die für Erfolg bzw. Misserfolg ausschlaggebenden Faktoren Regionaler Innovationssysteme und leitet Beurteilungskriterien für RIS ab. Anhand von Fallstudien werden sechs Hypothesen zu den Triebkräften für den Erfolg von RIS überprüft und gleichzeitig auf das Drei-Säulen-Konzept der Nachhaltigkeit bezogen. Das Untersuchungsfeld umfasst sowohl "Erfolgsregionen" als auch "Normalregionen", wobei deutsche und internationale Beispiele gleichermaßen berücksichtigt sind. Hieraus ergeben sich strategische Entwicklungsperspektiven sowie ein Set von Handlungsempfehlungen für die Träger von RIS in Deutschland.

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Free Download Regenerative Medicine and Cell Therapy By Ilyas Singec (auth.), Hossein Baharvand, Nasser Aghdami (eds.)
2013 | 318 Pages | ISBN: 1627030972 | PDF | 4 MB
Therapeutic applications within regenerative biomedicine has gained tremendous interest from a growing, multidisciplinary community of investigators in recent years, driven by the hope of finding cures for several diseases. Regenerative Medicine and Cell Therapy discusses cutting-edge science in the field of regenerative biomedicine and its therapeutic applications to various medical disorders. The chapters are written by renowned scientists in the specific fields. This will be a useful book for basic and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research. The editors' goal is that the new knowledge and research outlined in this book will help contribute to new therapies for a wide variety of diseases that presently afflict humanity.

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