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English | 2022 | ISBN: 0128222778 | 374 pages | True PDF EPUB | 44.88 MB Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research examines the steps in a preclinical pipeline that utilizes iPSC-derived neuronal technology to better understand neurological disorders and identify novel therapeutics, also providing considerations and best practices. By presenting example projects that identify phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy, this book allows readers to understand what considerations are important to assess at the start of project design. Sections address reproducibility issues and advances in technology at each stage of the pipeline and provide suggestions for improvement. From patient sample collection and proper controls to neuronal differentiation, phenotyping, screening, and considerations for moving to the clinic, these detailed descriptions of each stage of the pipeline will help everyone, regardless of stage in the pipeline.  English | 2022 | ISBN: 1119634601 | 563 pages | True PDF EPUB | 28.43 MB Explore the cutting-edge of dissolution testing in an authoritative, one-stop resource  English | 2022 | ISBN: 9781399097758 | 241 pages | True PDF EPUB | 53.61 MB This is the epic story of the Great Persian War of 481-479 BC, the major land and sea Persian invasion of Greece under Xerxes. Starting from the Persian decision to avenge the outrage caused to imperial prestige by the battle of Marathon, this book details the policy, diplomacy and religion as they intermingle with matters of strategy and tactics. It includes detailed coverage of the legendary Battle of Thermopylae, immortalized in literature and film as the ultimate defiant last stand. There is similarly in-depth coverage, in terms of events, tactics, methods and intentions, afforded to the relatively unknown sea battles off Cape Artemisium, only recently dramatized for the Big Screen; a naval engagement that primed the Battle of Salamis. Special attention has been paid to the events following these two battles, leading to the bloody conquest of Athens and the implementation of vengeance by the Persian Empire, which for a brief time stood triumphant, victorious and awesome as never before, but also sowed the seeds of eventual defeat.  English | 2022 | ISBN: 8770226822 | 124 pages | True PDF | 14.1 MB Urban expansion and the preservation of fringe landscapes are clearly interconnected issues. This book discusses the relationship between landscape and peri-urban agriculture and the possible implications of sustainable land management for fringe land quality, proposing a framework to evaluate the latent nexus between agro-forest systems and human settlements in Southern Europe. Eco-sustainable planning integrated with multi-faceted policy actions (social, economic, cultural and political dimensions) is a relevant approach to reinforce sustainability of fringe landscapes. Permanent assessment of these factors allows for the implementation of different development scenarios. The present work definitely contributes to systemic and multi-scale approaches informing environmental policies, with the aim of achieving an integrated management of peri-urban agricultural landscapes.  English | 2022 | ISBN: 0198871015 | 897 pages | True PDF EPUB | 9.87 MB In Perception: First Form of Mind, Tyler Burge develops an understanding of the most primitive type of mental representational: perception. Focusing on the functions and capacities of perceptual states, Burge accounts for their representational content and structure, and develops a formal semantics for them. The discussion explains the role of iconic format in the structure. It also situates the accounts of content, structure, and semantics within scientific  English | 2022 | ISBN: 012820141X | 792 pages | True PDF EPUB | 52.36 MB Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis.  English | 2022 | ISBN: 0691201129 | 201 pages | True PDF | 29.73 MB A fascinating exploration of the pentagon and its role in various cultures  English | 2022 | ISBN: 3030965414 | 1021 pages | True PDF EPUB | 91.49 MB Evidence-based, point-of-care information on 1000 diseases and disorders most often treated by surgeons  English | 2022 | ISBN: 1789146216 | 288 pages | True PDF | 13.99 MB This is a beautifully illustrated account of pearls through millennia, from fossils to contemporary jewellery. Pearls are the most human of gems, both miraculous and familiar. Uniquely organic in origin, they are as intimate as our bodies, created through the same process by which we grow bones and teeth. They have long been described as an animal's sacrifice, but until recently their retrieval often entailed the sacrifices of enslaved and indentured divers and labourers. 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