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Free Download Refining Processes for the Co-Development of Genome-Based Therapeutics and Companion Diagnostic Tests : Workshop Summary By Institute of Medicine; Board on Health Sciences Policy; Roundtable on Translating Genomic-Based Research for Health; Adam C. Berger; Steve Olson; Samuel G. Johnson; Sarah H. Beachy
2014 | 103 Pages | ISBN: 0309298210 | EPUB | 1 MB
Many drug developers have examined new strategies for creating efficiencies in their development processes, including the adoption of genomics-based approaches. Genomic data can identify new drug targets for both common and rare diseases, can predict which patients are likely to respond to a specific treatment, and has the potential to significantly reduce the cost of clinical trials by reducing the number of patients that must be enrolled in order to demonstrate safety and efficacy. A key component of the approval of targeted therapeutics is the ability to identify the population of patients who will benefit from treatment, and this has largely hinged on the co-development and co-submission to the FDA of a companion diagnostic test.The co-development process, or the development of the test and drug for the simultaneous submission to FDA, has led to a major alteration in the way that drugs are being developed, with traditionally separate entities-pharmaceutical and diagnostic companies-now working in close collaboration. Refining Processes for the Co-Development of Genome-Based Therapeutics and Companion Diagnostic Tests is the summary of a workshop held by the Roundtable on Translating Genomic-Based Research for Health on February 27, 2013 to examine and discuss challenges and potential solutions for the codevelopment of targeted therapeutics and companion molecular tests for the prediction of drug response. Prior to the workshop, key stakeholders, including laboratory and medical professional societies, were individually asked to provide possible solutions to resolve the concerns raised about co-development of companion diagnostic tests and therapies. Workshop speakers were charged with addressing these solutions in their presentations by providing insight on (1) whether the proposed solutions address the problems described, (2) whether there are other solutions to propose, and (3) what steps could be taken to effectively implement the proposed solutions.

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Free Download Refinancing America : The Republican Antitax Agenda By Sheldon D. Pollack
2002 | 295 Pages | ISBN: 0791455890 | PDF | 1 MB
A fascinating account of the long history of antitax sentiments within the Republican party, Refinancing America looks at how opposition to income and wealth taxation became the dominant factor influencing the party's political agenda. The countless proposals for tax cuts introduced by Republicans in Congress during the 1990s, as well as the Bush administration's $1.6 trillion tax cut in May 2001, were not aberrations, but rather the continuation of a long tradition of hostility to taxation. Nevertheless, the rhetoric and devotion to the antitax cause in the 1990s was more pronounced than in the past, and this book explains how this more extreme strain of antitax politics came to dominate the GOP.

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Free Download Fay Zipkowitz, "Reference Services for the Unserved "
English | ISBN: 1560247975 | 1996 | 108 pages | EPUB | 329 KB
New recognition within society of previously unserved populations has created the need for librarians to also recognize these groups and to find ways to serve them equally. Reference Services for the Unserved provides information, guidance, and inspiration to library professionals in their work with previously unserved populations so that these persons may be absorbed into the larger, served population groups. It helps librarians adjust to making accommodations for these new user groups, recognizing that many people in these populations have very specific needs and bring with them some specific limitations in their abilities to take advantage of existing library services. The Americans with Disabilities Act (ADA) has transformed the lives of disabled and challenged people by mainstreaming disabled children in public schools, moving mentally and developmentally disabled people into community-based residences and workshops, providing services to disabled college students, and enhancing workplace accommodations. At the same time, the ADA has presented new challenges for the library community. Reference Services for the Unserved guides library professionals in meeting these new challenges by bringing together research and descriptions of several successful attempts to meet the information needs of previously unserved populations. In guiding library professionals and administrators in effectively serving currently unserved populations, authors in Reference Services for the Unserved tell readers how to:

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Free Download Refereeing Identity : The Cultural Work of Canadian Hockey Novels By Michael Buma
2012 | 336 Pages | ISBN: 0773539875 | EPUB | 1 MB
Hockey novels in Canada have emerged and thrived as a popular fiction genre, building on the mythology of Canadian hockey as a rough, testosterone-fuelled bastion of masculinity. However, recent decades have also been a period of uncertainty and change for the game, where players and teams have been exported to the US and traditional gender assumptions in hockey have increasingly been questioned. In Refereeing Identity, Michael Buma examines the ways in which the hockey novel genre attempts to reassure readers that "threatened" traditional Canadian and masculine identities still thrive on the ice. In a period of perceived crisis and flux, hockey novels offer readers the comforting familiarity of earlier times when the game was synonymous with Canada and men were defined by their physical strength. This comprehensive study of Canadian hockey novels draws on history, sport sociology, and literary criticism to challenge assumptions and stereotypes about identity. With the return of the Winnipeg Jets refuelling hockey nationalism and the public debate over hockey violence intensifying, Refereeing Identity is a timely and incisive account of how the game is represented - and misrepresented - in Canadian society.

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Free Download Reeducating the Educator : Global Perspectives on Community Building By Helen Christiansen; S. Ramadevi; Editors,
2001 | 261 Pages | ISBN: 0791451216 | PDF | 1 MB
Reeducating the Educator focuses on community building within teacher education programs in Canada, Israel, Australia, and the United States. Maintaining that communities have to be built and sustained, the contributors discuss possible theoretical frameworks underlying community building and change and suggest that there is a need for teacher educators to go beyond localized experiences and reach out to one another in a global discussion. Because of the impact of local cultures and histories, key questions and issues vary from one country to another, and even from one faculty to another, but the resulting global conversation provides a greater understanding of the professional development of teachers and teacher educators.

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Free Download Barak Ariel, "Reducing the Risk of Workplace Violence Against Public-Facing Employees: Findings from a Mix-Methods Study of Body-Worn "
English | ISBN: 3031463552 | 2023 | 87 pages | EPUB | 4 MB
This brief investigates the usefulness of Body-worn videos (BWVs) in non-policing environments. The first study of this kind, this research presents new datasets related to these devices, including:

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Free Download Brian C. Miller, "Reducing Secondary Traumatic Stress"
English | ISBN: 0367494574 | 2021 | 190 pages | EPUB | 1316 KB
Reducing Secondary Traumatic Stress presents a model for supporting emotional well-being in workers who are exposed to the effects of secondary trauma. The book provides helping professionals with a portfolio of skills that supports emotion regulation and recovery from secondary trauma exposure and also that enhances the experience of the helping encounter. Each chapter presents evidence-informed skills that allow readers to regulate distressing emotions and to foster increased empathy for those suffering from trauma. Reducing Secondary Traumatic Stress goes beyond the usual discussion of burnout to talk in specific terms about what we do about the very real stress that is produced by this work.

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Free Download Reducing Disaster Losses Through Better Information By National Research Council; Division on Earth and Life Studies; Environment and Resources Commission on Geosciences; Board on Natural Disasters
1999 | 71 Pages | ISBN: 0309063396 | EPUB | 1 MB
Losses of life and property from natural disasters in the United States-and throughout the world-have been enormous and the potential for substantially greater future losses looms. It is clearly in the public interest to reduce these impacts and to encourage the development of communities that are resilient to disasters. This goal can be achieved through wise and sustained efforts involving mitigation, preparedness, response, and recovery. Implementing such efforts, particularly in the face of limited resources and competing priorities, requires accurate information that is presented in a timely and appropriate manner to facilitate informed decisions. Substantial information already exists that could be used to this end, but there are numerous obstacles to accessing this information, and methods for integrating information from a variety of sources for decision-making are presently inadequate. Implementation of an improved national or international network for making better information available in a more timely manner could substantially improve the situation. As noted in the Preface, a federal transition team is considering the issues and needs associated with implementing a global or national disaster information network as described in the report by the Disaster Information Task Force (1997). This National Research Council report was commissioned by the transition team to provide advice on how a disaster information network could best make information available to improve decision making, with the ultimate goal of reducing losses from natural disasters. The report is intended to provide the basis for a better appreciation of which types of data and information should be generated in an information program and how this information could best be disseminated to decision makers.

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Free Download Redrawing Humanity's Map: How Climate Change Is Shaping Migration
English | 2025 | ISBN: 3031859863 | 190 Pages | PDF (True) | 9 MB
Climate shocks are shaping human geographies, threatening coastlines, flooding settlements and heating up cities. Therefore, climate impacts and the associated environmental changes are increasingly reflected in social systems. Based on eight years of research, this book sheds light on the impact of climate extremes on migration and displacement. It provides insights into the different contexts in which people experience the effects of climate change and how they shape migration decisions. In the absence of a supranational governance framework, individuals and institutions are already searching for sustainable solutions across the migration cycle to uplift communities. This book builds on qualitative interviews and focus group discussions in numerous countries with people who had to leave their ancestral homelands due to climate impacts, with groups trying to support them, and also with those who want to prevent migration. These exchanges produced not only a body of scientific work, but also a complex overall picture and personal impressions of the state of our planet and the people who live on it.

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Free Download Redesigning the Financial Aid System : Why Colleges and Universities Should Switch Roles with the Federal Government By Robert B. Archibald
2002 | 255 Pages | ISBN: 0801877598 | PDF | 1 MB
As the cost of higher education continues to rise, students and their families find it increasingly difficult to navigate the financial aid maze. In Redesigning the Financial Aid System, economist Robert Archibald examines the history of the system and its current flaws, and he makes a radical proposal for changing the structure of the system. Archibald argues that one of the problems with the current model--in which universities are responsible for the majority of grants while the federal government provides student loans--is that a student cannot know the final price of attending a given institution until after he or she has applied, been accepted, and received a financial aid offer. As a result, students remain largely uninformed about the cost of their college educations until very late in the decision-making process and so have difficulty making a timely choice. In addition, financial aid information is kept private, creating confusion over the price of a college education and the role of financial aid. Under Archibald's proposed reforms, the federal government would assess a student's financial need and provide need-based grants, while institutions would be responsible for guaranteeing student loans. Not only would this new system demystify financial aid and allow students to be better informed about the cost of college earlier in the process, but it would greatly simplify the application procedure and prevent financial aid allocation from contributing to the problem of rising tuition costs. Archibald's clear explanation of the current system--its impact, strengths, and weaknesses--as well as his plans for reform, will be of interest to educators, administrators, students, and parents.

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