Galectins and Disease Implications for Targeted Therapeutics

Galectins and Disease Implications for Targeted Therapeutics By Anatole A. Klyosov and Peter G. Traber (Eds.)
2012 | 425 Pages | ISBN: 0841228809 | PDF | 12 MB
Content: CONTENTS ; PREFACE ; OVERVIEW ; 1. GALECTINS IN DISEASE AND POTENTIAL THERAPEUTIC APPROACHES ; ANATOLE A. KLYOSOV AND PETER G. TRABER ; GALECTIN AND GALECTIN INHIBITORS: STRUCTURAL ASPECTS ; 2. LOW-MOLECULAR WEIGHT INHIBITORS OF GALECTINS ; HAKON LEFFLER AND ULF J. NILSSON ; 3. FROM CARBOHYDRATE TO PEPTIDOMIMETIC INHIBITORS OF GALECTINS ; KEVIN H. MAYO ; GALECTIN EXTRA- AND INTRA-CELLULAR FUNCTIONS AND ; THEIR THERAPEUTIC IMPLICATIONS ; 4. INTRACELLULAR GALECTINS: PLATFORMS FOR ASSEMBLY OF MACROMOLECULAR ; COMPLEXES ; JOHN L. WANG, KEVIN C. HAUDEK, PATRICIA G. VOSS, RONALD J. PATTERSON, AND ; ERIC J. ARNOYS ; 5. GALECTINS AS NOVEL REGULATORS OF PLATELET SIGNALING AND FUNCTION: ; THERAPEUTIC IMPLICATIONS ; GABRIEL A. RABINOVICH AND MIRTA SCHATTNER ; 6. GALECTIN-1 CROSS-LINKING OF GM1 GANGLIOSIDE IN AUTOIMMUNE ; SUPPRESSION ; ROBERT W. LEDEEN, GUSHENG WU, DAVID BLEICH, ZI-HUA LU, AND HANS-JOACHIM GABIUS ; 7. HOW TO BUILD "LEAN AND MEAN" ANTI-TUMOR T CELLS: A STRATEGIC VIEW INTO ; THE ANTI-CARBOHYDRATE ACTION OF FLUORINATED GLUCOSAMINE ANALOGS ; CHARLES J. DIMITROFF ; 8. POST-TRANSLATIONAL MODIFICATION OF GALECTIN-3 AND ITS ROLE IN BIOLOGICAL ; FUNCTION ; JAMES C. BYRD, NACHMAN MAZUREK, AND ROBERT S. BRESALIER ; GALECTIN MECHANISMS AND THERAPEUTIC APPROACHES IN CANCER ; 9. THE ROLE OF GALECTIN-3 IN MALIGNANT MELANOMA ; GORDANA RADOSAVLJEVIC, IVAN JOVANOVIC, JELENA PANTIC, NADA PEJNOVIC, ; NEBOJSA ARSENIJEVIC, DANIEL K. HSU, AND MIODRAG L. LUKIC ; 10. GALECTINS AS NOVEL TARGETS FOR THE TREATMENT OF MALIGNANT GLIOMAS ; HERWIG M. STRIK AND MATTHIAS OCKER ; 11. DYNAMIC TUNING OF GALECTINS AND THEIR BINDING SITES DURING MAMMARY ; TUMOR PROGRESSION AND METASTASIS ; JOANA T. DE OLIVEIRA AND FATIMA GARTNER ; 12. GALECTIN-3C: HUMAN LECTIN FOR TREATMENT OF CANCER ; GARY A. JARVIS, LEONARDO MIRANDOLA, YU YUEFEI, EVERARDO COBOS, ; MAURIZIO CHIRIVA-INTERNATI, AND CONSTANCE M. JOHN ; 13. ANGIOSTATIC CANCER THERAPY BY TARGETING GALECTINS IN THE TUMOR ; VASCULATURE ; IRIS A. SCHULKENS, ARJAN W. GRIFFIOEN, AND VICTOR L. THIJSSEN ; 14. GALECTINS AND PATHOLOGIES: ROLE OF GALECTIN-3 IN THE COMMUNICATION ; BETWEEN LEUKEMIA CELLS AND THE MICROENVIRONMENT ; NORA HEISTERKAMP, FEI FEI, AND JOHN GROFFEN ; 15. TRANSLATIONAL RATIONAL FOR THE CLINICAL DEVELOPMENT OF OTX-008: A NOVEL ; DRUG THAT INHIBITS GALECTIN-1 EXPRESSION IN HUMAN CANCER MODELS ; ERIC RAYMOND, LUCILE ASTRORGUE-XERRI, MARIA SEROVA, MARIA EUGENIA RIVEIRO, AND ; SANDRINE FAIVRE ; 16. IMPROVING THE CLINICAL EFFICACY OF CANCER VACCINES BY TARGETING IMMUNE ; SUPPRESSION IN HUMAN TUMORS ; NATHALIE DEMOTTE, ARISTOTELIS ANTONOPOULOS, JEAN-FRANCOIS BAURAIN, GREGOIRE WIEERS, ; NICOLAS VAN BAREN, AND PIERRE VAN DER BRUGGEN ; 17. TARGETING GALECTIN-3 UNVEILS THE COMPLEXITY OF MULTIPLE MYELOMA: A ; SWEET CONTEXT ; LEONARDO MIRANDOLA, YUEFEI YU, CONSTANCE M. JOHN, MARJORIE JENKINS, ; EVERARDO COBOS, AND MAURIZIO CHIRIVA-INTERNATI ; 18. GALECTINS IN THE BLOOD CIRCULATION: POTENTIAL THERAPEUTIC TARGETS OF ; CANCER METASTASIS ; CARRIE A. DUCKWORTH AND LU-GANG YU ; GALECTIN MECHANISMS AND THERAPEUTIC APPROACHES IN ; INFLAMMATION AND FIBROSIS ; 19. A THERAPEUTIC ROLE FOR GALECTINS IN ACUTE INFLAMMATION? ; DIANNE COOPER ; 20. GALECTINS IN IMMUNE AND INFLAMMATORY DISEASES: INSIGHTS FROM ; EXPERIMENTS WITH GALECTIN DEFICIENT MICE ; DANIEL K. HSU, RI-YAO YANG, AGNES FERMIN, AND FU-TONG LIU ; 21. AUTOIMMUNE DISORDERS IN GALECTIN-3 DEFICIENT MICE ; VLADISLAV VOLAREVIC AND MIODRAG L. LUKIC ; 22. GALECTIN-3: A CENTRAL REGULATOR OF CHRONIC INFLAMMATION AND TISSUE ; FIBROSIS ; NEIL C. HENDERSON, ALISON C. MACKINNON, CLAIRE ROONEY, AND TARIQ SETHI ; 23. THE ROLE OF GALECTIN-3 IN STELLATE CELL ACTIVATION AND LIVER FIBROSIS ; JOY X. JIANG, XIANGLING CHEN, HIROO FUKADA, DAN K. HSU, FU-TONG LIU, AND ; NATALIE J. TOROK ; 24. GALECTIN-3 MEDIATED CARDIOVASCULAR FIBROGENESIS: AN IMPORTANT CAUSE OF ; HEART FAILURE AND CARDIOVASCULAR MORTALITY ; WOUTER C. MEIJERS AND RUDOLF A. DE BOER ; 25. MUCINS AND GALECTIN-3 IN OCULAR SURFACE HEALTH AND DISEASE ; JEROME MAURIS AND PABLO ARGUESO ; 26. ROLE OF GALECTINS IN WOUND HEALING ; NOORJAHAN PANJWANI, PH.D. ; EDITORS' BIOGRAPHIES ; INDEXES ; AUTHOR INDEX ; SUBJECT INDEX