Pharmacogenomics in Clinical Therapeutics

Pharmacogenomics in Clinical Therapeutics By
2012 | 249 Pages | ISBN: 0470657340 | PDF | 3 MB
Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on traditional therapeutic drug monitoring. Pharmacogenomics in Clinical Therapeutics provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drug-drug interactions. From a team of expert contributors, Pharmacogenomics in Clinical Therapeutics is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field.Content: Chapter 1 Pharmacogenomics Principles: Introduction to Personalized Medicine (pages 1-14): Parvaz Madadi and Gideon KorenChapter 2 Traditional Therapeutic Drug Monitoring and Pharmacogenomics: Are They Complementary? (pages 15-25): Christine L. H. Snozek, Loralie J. Langman and Amitava DasguptaChapter 3 Pharmacogenomics Aspect of Warfarin Therapy (pages 26-38): Matthew D. KrasowskiChapter 4 Pharmacogenetics and Cancer Chemotherapy (pages 39-52): Christine L. H. SnozekChapter 5 Pharmacogenomic Considerations in Anesthesia and Pain Management (pages 53-69): Christine M. Formea and Wayne T. NicholsonChapter 6 Pharmacogenomics of Immunosuppressants (pages 70-97): Nicolas Picard and Pierre MarquetChapter 7 Pharmacogenomics of Cardiovascular Drugs (pages 98-126): Linnea M. BaudhuinChapter 8 Pharmacogenomic Aspects of Antiretroviral Therapy (pages 127-143): Natella Y. Rakhmanina and John N. van den AnkerChapter 9 Pharmacogenetics of Psychoactive Drugs (pages 144-175): Jorge L. SepulvedaChapter 10 Pharmacogenomic Aspects of Adverse Drug-Drug Interactions (pages 176-184): Loralie J. Langman and Christine L. H. SnozekChapter 11 Microarray Technology and Other Methods in Pharmacogenomics Testing (pages 185-200): Jorge L. SepulvedaChapter 12 Pharmacogenetic Testing in the Clinical Laboratory Environment (pages 201-223): Mark P. Borgman and Mark W. Linder