Retrotransposons and Human Disease L1 Retrotransposons as a Source of Genetic Diversity

This volume explores an array of diseases in humans associated with L1 retrotransposon movement within the human genome, including some cancers such as colon cancer and neuropsychiatric disorders such as schizophrenia.
The chapters explore the diversity of retrotransposons, their different biological mechanisms, the role of L1 in their movement, and their contribution to human diseases. This book posits that somatic events caused by retrotransposons have implications for mosaicism and are often associated with cancers. Germline events are common, occur quite early in development, and are a cause of single gene diseases. All in all, the authors implicate L1 retrotransposons as major sources of human diversity and advocate for their continued study.
Contents:PrefaceThe Diversity of Reverse Transcriptases (Blair G Paul, Irina A Yushenova, and Irina R Arkhipova)Ty3 and Related LTR-Retrotransposon Reverse Transcriptases (Jennifer T Miller and Stuart F J Le Grice)Experimental Systems for the Study of Non-LTR (LINE) Retrotransposons (Ivana Celic and Jeffrey S Han)Alu Elements and Human Disease (Hanlin Yang, Maria E Morales, and Astrid M Roy-Engel)Retrotransposition as a Cause of Human Disease: An Update (Haig H Kazazian)LINE-1 Retrotransposons, Stem Cells, and Human Neurodevelopmental Disorders (Maria Benitez-Guijarro, Meriem Benkaddour-Boumzaouad, and Jose L Garcia-Perez)Retrotransposition Mechanisms and Host Factors (Siew Loon Ooi, Kathleen H Burns, and Jef D Boeke)Retrotransposons in the Mammalian Brain (Tracy A Bedrosian, Sara B Linker, and Fred H Gage)LINE-1 Mobilization in Cancers: More the Rule than the Exception (Daniel Ardeljan and Kathleen H Burns)Index
Readership: Researchers from both academia and industry, graduate students, premed students, clinicians.