Neurobiology of DOPA as a Neurotransmitter

The book begins with a historical review of current knowledge of DOPA. It characterizes DOPA as a prominent example showing transmutation from an inert substance to a gold drug in Parkinson's disease and further to a neurotransmitter in its own right. The next chapters cover the essential criteria of a neurotransmitter such as synthesis, existence, and competitive antagonism. The book describes metabolism composed of catecholamine synthesis and degradation products related to neuron death, physiological release of DOPA in the lower brainstem, striatum, and nucleus accumbens, and physiological or pharmacological responses involved in baroreflex neurotransmission and related to behavioral science including interactions with catecholamines, acetylcholine, glutamate, and GABA. The book explores recognition sites, transport sites, and therapeutic role and mechanisms for neuron death related to adverse influence in the treatment of Parkinson's Disease.
Edited by experts in the field, the breadth and depth of information contained in this book is confirmed by a quick scan of the chapter authors. They summarize the issues surrounding DOPA neurotoxicity and explore the link between experimental studies and clinical relevance.


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