Multi–Dimensional Liquid Chromatography Principles, Practice, and Applications (Repost)

This text, organized by two leaders in the field, establishes a sound fundamental basis for the principles of the technique, followed by a discussion of important practical considerations. The book begins with an introduction to multi-dimensional separations and a discussion of the history and development of the technique over the past 40 years, followed by several chapters that provide a theoretical basis for development of 2D-LC methods, including foundational concepts regarding separation complementarity, under-sampling, and dynamics of liquid chromatography separations. Instrumentation for 2D-LC is discussed extensively, including practical aspects such as interface selection and setup. Building on this foundation, two separate chapters are focused on method development for non-comprehensive and comprehensive separations, followed by a chapter dedicated to data analysis. Finally, applications of 2D-LC in several fields ranging from pharmaceutical analysis to polymer science are summarized.
The book is an important resource for both students and practitioners who are already using 2D-LC or are interested in getting started in the field.
Key Features:
- Demonstrates the conditions under which a 2D-LC method should be considered as an alternative to a 1D-LC method
- Establishes a sound fundamental basis of the principles of the technique, followed by guidelines for method optimization
- Provides a single source for technical knowledge advances and practical guidance described in recent literature
- Assists with the initial decision to develop a 2D-LC method
- Guides the reader in developing a high-quality method that meets the needs of their application


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