Hepatic Arterial Infusion for Malignancy
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English | 2025 | ISBN: 3031749340 | 792 Pages | PDF EPUB (True) | 81 MB
Hepatic Arterial Infusion (HAI) chemotherapy most commonly entails the surgical implantation of a subcutaneous pump with a catheter that is inserted into the hepatic arterial system, allowing for the delivery of high-dose chemotherapy directly to the liver, typically given concurrently with systemic chemotherapy. The primary agent delivered via HAI is floxuridine (FUDR), which has the ideal properties of a short half-life (<10 minutes) and near-complete hepatic clearance, such that drug concentrations in the liver reach up to 400 times that which could be achieved with intravenous delivery, but without systemic exposure/toxicity.
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