Nanocrystal Technologies in Biomedical Sciences

In pharmaceutical and biomedical sciences, addressing poor bioavailability is of paramount importance in drug development. Innovative strategies are being employed to enhance the solubility, dissolution rate, and physiochemical properties of Biopharmaceutical Classification System (BCS) II and IV drugs. Drug nanocrystals have emerged as a solution by leveraging the crystalline nature of drugs to address critical challenges. This carrier-free colloidal drug delivery system operates at the nano-size range, where the crystalline drug particle core is enveloped by a stabilizing agent (surfactant/polymer). However, selecting a stabilizer remains a persistent challenge for certain drug molecules.

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