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  Author: creativelivenew1   |   17 September 2024   |   Comments icon: 0
Pediatric Endocrinology A Practical Clinical Guide, Second Edition
Free Download Pediatric Endocrinology: A Practical Clinical Guide, Second Edition By Christopher J. Romero M.D., Andrew N. Dauber M.D., Laurie E. Cohen M.D. (auth.), Sally Radovick, Margaret H. MacGillivray (eds.)
2013 | 624 Pages | ISBN: 1607613948 | PDF | 12 MB
A state-of-the-art and concise guide to the clinical management of pediatric endocrine disorders, the second edition of the highly regarded Pediatric Endocrinology: A Practical Clinical Guide covers the most common and challenging conditions seen by practicing endocrinologists and primary care physicians, including growth, hypothalamic, pituitary, adrenal, thyroid, calcium and bone, and reproductive disorders, as well as metabolic syndromes. This expanded second edition includes new topics being seen more commonly in pediatric endocrinology practices related to obesity and type 2 diabetes mellitus and lipid disorders. Each chapter contains an introductory discussion of the problem, a review of the clinical features that characterize it, the criteria needed to establish a diagnosis, and a comprehensive therapy section delineating the risks and benefits of the best therapeutic options available. Invaluable tables summarize the critical factors in etiology, clinical presentation, diagnosis, and therapeutic dosages. Pediatric Endocrinology: A Practical Clinical Guide, Second Edition, is a comprehensive resource for all clinicians concerned with the myriad endocrinologic disorders seen in children and adolescents.

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  Author: creativelivenew1   |   17 September 2024   |   Comments icon: 0
Patterns of the Heart and Other Stories
Free Download Myŏngik Ch'oe, "Patterns of the Heart and Other Stories "
English | ISBN: 0231202709 | 2024 | 304 pages | PDF | 2 MB
Korean writer Ch'oe Myŏngik was a lifelong resident of Pyongyang, a city his short stories masterfully evoke in exquisite modernist prose. His career spanned decades of tumult, from his debut in the 1930s while Korea was under Japanese colonial rule through the Asia-Pacific and Korean Wars and the early years of the Democratic People's Republic. As Pyongyang transformed from Korea's second city, peripheral to the Seoul-centered literary scene, into a socialist capital in the late 1940s, Ch'oe briefly ascended to the center of North Korean culture. Despite the vitality and originality of Ch'oe's writing, Cold War politics and censorship, including South Korea's anticommunist laws, consigned his work to obscurity.

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  Author: creativelivenew1   |   17 September 2024   |   Comments icon: 0
Pathology of the Pancreas A Practical Approach (2024)
Free Download Pathology of the Pancreas: A Practical Approach by Fiona Campbell
English | EPUB | 2021 | 438 Pages | ISBN : 3030498476 | 843.9 MB
This updated volume provides a practical guide to pancreatic pathology that covers recent changes in concepts and classifications. Potential pitfalls and mimics in pancreatic pathology are highlighted and illustrated, and guidance is provided regarding how to recognise and avoid them. There is a new chapter on transplant pathology, and more than 200 new macroscopic and microscopic images have been added.

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  Author: creativelivenew1   |   17 September 2024   |   Comments icon: 0
Patho–Epigenetics of Disease
Free Download Patho-Epigenetics of Disease By Walter Doerfler MD (auth.), Janos Minarovits, Hans Helmut Niller (eds.)
2012 | 466 Pages | ISBN: 1461433444 | PDF | 5 MB
In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences.Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to "remember" their proper cellular identity. An alternative system of epigenetic memory, the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression via modification of histone tails. The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transmission of gene expression patterns to each progeny cell upon division. These carefully orchestrated processes can go wrong, however, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes, as it was first realized during the studies of epigenetic alterations in malignant tumors. By now it became a well established fact that not only genetic changes, but also the disruption of epigenetic regulation can result in carcinogenesis and tumor progression. Scientists working in other fields soon followed the pioneering work of cancer researchers, and revealed that epigenetic dysregulation forms the basis of a wide spectrum of human diseases.

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  Author: creativelivenew1   |   17 September 2024   |   Comments icon: 0
Party–Voter Linkage in Africa Ghana and Senegal in Comparative Perspective
Free Download Party-Voter Linkage in Africa: Ghana and Senegal in Comparative Perspective By Anja Osei (auth.)
2012 | 307 Pages | ISBN: 3531186124 | PDF | 2 MB
Parties in Africa are often described as organisationally and programmatically weak. On the other hand, they mobilise substantial numbers of voters at election time. This contradiction provokes an interesting question: How do political parties in Africa relate to the society? How do they mobilise their voters and sympathisers, and which strategies do they employ?Anja Osei analyses how parties in Ghana and Senegal adapt to their local context by employing locally embedded strategies.

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  Author: creativelivenew1   |   17 September 2024   |   Comments icon: 0
Pakistan at the Crossroads Domestic Dynamics and External Pressures
Free Download Christophe Jaffrelot, "Pakistan at the Crossroads: Domestic Dynamics and External Pressures "
English | ISBN: 0231173067 | 2016 | 360 pages | EPUB | 1455 KB
In Pakistan at the Crossroads, top international scholars assess Pakistan's politics and economics and the challenges faced by its civil and military leaders domestically and diplomatically. Contributors examine the state's handling of internal threats, tensions between civilians and the military, strategies of political parties, police and law enforcement reform, trends in judicial activism, the rise of border conflicts, economic challenges, financial entanglements with foreign powers, and diplomatic relations with India, China, Iran, Saudi Arabia, Afghanistan, and the United States.

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  Author: creativelivenew1   |   17 September 2024   |   Comments icon: 0
Oxford Phonics Spelling Dictionary
Free Download Roderick Hunt, "Oxford Phonics Spelling Dictionary"
English | ISBN: 019273413X | 2001 | pages | PDF | 17 MB
The brand new Oxford Phonics Spelling Dictionary is an easy home and school reference tool. It supports the teaching of reading and spelling through synthetic phonics. Supported by the Floppy's Phonics Sounds and Letters Programme, it follows the Alphabetic Code Chart showing the sounds and alternative spellings that children will need to learn to become proficient readers and spellers. The words are ordered by initial sound and there are subsections to show how the same sounds appear in the middle or at the end of a word. The long vowel sounds and their alternative spellings appear in a separate section within the dictionary. This unique dictionary makes it easy to explain how 'sun' and 'Cinderella' both start with the 's' sound and how 'dance' has the same 's' sound at the end, while 'egg' and 'eat' start with the same letter but different sounds. With colourful illustrations by Alex Brychta and the familiar Oxford Reading Tree characters, this is a fun way to prepare for the phonics screening check. There is additional phonics support material and audio on the Oxford Owl website,http://www.oxfordowl.co.uk. For more free downloadable word games, puzzles, and activities go online towww.oxforddictionaries.com/schools.

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  Author: creativelivenew1   |   17 September 2024   |   Comments icon: 0
Our Land, Our Oil! Natural Resources, Local Nationalism, and Violent Secession
Free Download Our Land, Our Oil!: Natural Resources, Local Nationalism, and Violent Secession By Stefano Casertano (auth.)
2013 | 290 Pages | ISBN: 3531194429 | PDF | 3 MB
Stefano Casertano explores the connections between the presence of energy natural resources and the development of "local nationalism" in the producing regions. In particular, he applies a specific focus on those cases where such nationalism leads to secession attempts. The research is based on eight case studies in Bolivia, Sudan, Malaysia, Indonesia, China, Iran, Angola, and Nigeria.

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  Author: creativelivenew1   |   17 September 2024   |   Comments icon: 0
Operative Neuromodulation Volume 2 Neural Networks Surgery
Free Download Operative Neuromodulation: Volume 2: Neural Networks Surgery By Damianos E. Sakas, I. G. Panourias, B. A. Simpson (auth.), Damianos E. Sakas, Brian A. Simpson (eds.)
2007 | 590 Pages | ISBN: 3211330801 | PDF | 11 MB
Neuromodulation is a rapidly evolving multidisciplinary biomedical and biotechnological field. The two volumes present the state-of-the-art in established and emerging applications for pain, spasticity, movement disorders, bladder and bowel dysfunction, cardiovascular disease, epilepsy, psychiatric illness, impairment of hearing and vision, and computational neuromodulation. Experts describe the neural networks involved and the appropriate surgical approaches, provide clinical guidelines, technical descriptions of implanted devices, proposals for refinements and personal views on future prospects of the field. The immense therapeutic potential is highlighted which arises from the close collaboration of biomedical scientists and biotechnological engineers in this area and signifies the transition from the conventional "resective" surgery to functional neuroprosthetic surgery (Vol. I) and neural networks surgery (Vol. II) which uses neuro-engineering to improve impaired neural function.Vol. 2 describes the techniques and procedures applied by direct a) contact with the central nervous system or cranial nerves, in order to modulate the function of neural networks as in the case of motor cortext stimulation for pain or vagus nerve stimulation for epilepsy, or b) in deeply located structures inside the nervous system, in order to alter the function on specific networks as in the case of deep brain stimulation for Parkinson's disease.

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  Author: creativelivenew1   |   17 September 2024   |   Comments icon: 0
Operative Neuromodulation Volume 1 Functional Neuroprosthetic Surgery. An Introduction
Free Download Operative Neuromodulation: Volume 1: Functional Neuroprosthetic Surgery. An Introduction By Damianos. E. Sakas, I. G. Panourias, B. A. Simpson, E. S. Krames (auth.), Damianos E. Sakas, Brian A. Simpson, Elliot S. Krames (eds.)
2007 | 486 Pages | ISBN: 321133078X | PDF | 9 MB
Neuromodulation is a rapidly evolving multidisciplinary biomedical and biotechnological field. The two volumes present the state-of-the-art in established and emerging applications for pain, spasticity, movement disorders, bladder and bowel dysfunction, cardiovascular disease, epilepsy, psychiatric illness, impairment of hearing and vision, and computational neuromodulation. Experts describe the neural networks involved and the appropriate surgical approaches, provide clinical guidelines, technical descriptions of implanted devices, proposals for refinements and personal views on future prospects of the field. The immense therapeutic potential is highlighted which arises from the close collaboration of biomedical scientists and biotechnological engineers in this area and signifies the transition from the conventional "resective" surgery to functional neuroprosthetic surgery (Vol. I) and neural networks surgery (Vol. II) which uses neuro-engineering to improve impaired neural function.Volume I describes techniques and procedures applied in internal contact with non-neural tissues surrounding the nervous system (dura or cerebrospinal fluid), as in the case of epidural stimulation for pain, etc. or intrathecal drug application for the treatment of spasticity and pain. There is also a special section on non-invasive functional neuroprosthetic systems, which are usually applied by transcutaneous contact with the nervous system.

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