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If you're looking for free educational programs or materials in the US and Canada, we'll help you find what you need for students and learners. ![]() Free Download Bioequivalence Studies in Drug Development: Methods and Applications By Dieter Hauschke, Volker Steinijans, Iris Pigeot(auth.) 2007 | 321 Pages | ISBN: 0470094753 | PDF | 7 MB Studies in bioequivalence are the commonly accepted method to demonstrate therapeutic equivalence between two medicinal products. Savings in time and cost are substantial when using bioequivalence as an established surrogate marker of therapeutic equivalence. For this reason the design, performance and evaluation of bioequivalence studies have received major attention from academia, the pharmaceutical industry and health authorities. Bioequivalence Studies in Drug Development focuses on the planning, conducting, analysing and reporting of bioequivalence studies, covering all aspects required by regulatory authorities. This text presents the required statistical methods, and with an outstanding practical emphasis, demonstrates their applications through numerous examples using real data from drug development. Includes all the necessary pharmacokinetic background information. Presents parametric and nonparametric statistical techniques. Describes adequate methods for power and sample size determination. Includes appropriate presentation of results from bioequivalence studies. Provides a practical overview of the design and analysis of bioequivalence studies. Presents the recent developments in methodology, including population and individual bioequivalence. Reviews the regulatory guidelines for such studies, and the existing global discrepancies. Discusses the designs and analyses of drug-drug and food-drug interaction studies. Bioequivalence Studies in Drug Development is written in an accessible style that makes it ideal for pharmaceutical scientists, clinical pharmacologists, and medical practitioners, as well as biometricians working in the pharmaceutical industry. It will also be of great value for professionals from regulatory bodies assessing bioequivalence studies.Content: Chapter 1 Introduction (pages 1-16): Chapter 2 Metrics to Characterize Concentration?Time Profiles in Single? and Multiple?Dose Bioequivalence Studies (pages 17-36): Chapter 3 Basic Statistical Considerations (pages 37-68): Chapter 4 Assessment of Average Bioequivalence in the RT/TR design (pages 69-104): Chapter 5 Power and Sample Size Determination for Testing Average Bioequivalence in the RT/TR Design (pages 105-122): Chapter 6 Presentation of Bioequivalence Studies (pages 123-155): Chapter 7 Designs with more than Two Formulations (pages 157-173): Chapter 8 Analysis of Pharmacokinetic Interactions (pages 175-203): Chapter 9 Population and Individual Bioequivalence (pages 205-282): Chapter 10 Equivalence Assessment for Clinical Endpoints (pages 283-306): ![]() Free Download Biodiversity: Exploring Values and Priorities in Conservation By Dan L. Perlman, Glenn Adelson(auth.) 1997 | 197 Pages | ISBN: 086542439X | PDF | 15 MB Biodiversity has become a buzzword in the environmental movement and in science, and is increasingly being taught in university degree courses. This new text is designed as a primer, giving non-specialists an introduction to the historical context, current debates, and ongoing research in this subject. Content: Chapter 1 Legacies (pages 1-17): Chapter 2 Conceptual Problems with Biodiversity (pages 18-36): Chapter 3 The Role of Values (pages 37-51): Chapter 4 Diversity (pages 52-66): Chapter 5 Mapping the Patterns of Biodiversity (pages 67-101): Chapter 6 Ambiguities (pages 102-124): Chapter 7 Inventories (pages 125-138): Chapter 8 Articulating Goals and Setting Priorities (pages 139-154): Chapter 9 Future Directions (pages 155-169): ![]() Free Download Bioceramics: Materials and Applications V, Volume 164 By 2006 | 128 Pages | ISBN: 1574981854 | PDF | 8 MB This proceedings includes papers on ceramics and glasses used in biomedical, dental and biological applications, including biomimetics and natural bioceramic materials. 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