Unraveling The World Of Molecular Genetics

What you'll learn
A deeper insight into major molecular mechanisms- replication, transcription, translation, and how they evolved
Meselsen-Stahl experiment, Theta mode of replication, okazaki fragements and discontinous mode of replication
Discovery of mRNA, ribosome composition, direction of translation and protein synthesis
Discovery of RNA polymerase and mechanism of transcription
Path-breaking experimental strategies that shaped the world of molecular biology as we know now
DNA- protein interaction assays
How an approach, integrating knowledge from diverse fields such as chemistry, biochemistry and mathematics, led to the understanding of the composition of genetic material as well as the genetic code
Elucidation of the genetic code
Experimental evidence for - DNA/RNA as the genetic material
Requirements
Students should have a basic knowledge in biology and chemistry. An understanding of nucleic acids and their roles in information transfer would be an added advantage.
Description
This Online Molecular Genetics course focuses on understanding and appreciating the genius of great scientists who made significant contributions in molecular biology with limited resources during their times. Current advances in this field are due to their pioneering efforts. The objective of the course is to unravel those underlying thinking processes for furthering creative research and designing unique experimental methods.In this online course in molecular biology, you'll learn about - Chemical, biochemical and structural evidence for DNA/RNA as genetic materialDNA -protein interactions experiments that revealed the DNA sequence to which DNA interacting proteins bind toExperiments unraveling the mechanism of DNA replication. Eg- Meselsen-stahl experimentDiscovery of protein synthesis machinery- mRNA, tRNA and ribosomesExperiments done to decipher the mechanism of transcriptionElucidation of the genetic codeAll these experiments revealed the central dogma of molecular biology.Each section of this online course is packed with quizzes to apply the information you have learnt in the lectures.This course is for students with a basic background in biology and chemistry. This course comes with a 30-day money back guarantee, so there is nothing to lose.Enroll in the course today and learn how the molecular mechanisms at the Replication, transcription and translation level were deciphered.
Overview
Section 1: Introduction
Lecture 1 Introduction
Section 2: DNA/RNA as genetic material
Lecture 2 Chemical evidence for genetic material
Lecture 3 Biochemical evidence for Genetic material
Lecture 4 Structural evidence for Genetic material
Section 3: Assays for DNA-protein interactions
Lecture 5 Assays for DNA-protein interactions part 1
Lecture 6 Assays for DNA-protein interactions part 2
Section 4: Experiments showing the mechanism of replication
Lecture 7 Meselsen and Stahl's experiment
Lecture 8 Analogy for mode of replication
Lecture 9 mode of replication
Lecture 10 Semi-discontinuous replication
Lecture 11 concepts introduced
Lecture 12 RNA priming
Lecture 13 Techniques used for RNA priming
Section 5: Translation machinery
Lecture 14 Discovery of mRNA part 1
Lecture 15 Crick and Jacob hypothesis
Lecture 16 Discovery of mRNA part 2
Lecture 17 Ribosome composition
Lecture 18 discovery of tRNA
Lecture 19 Direction of translation and protein synthesis
Lecture 20 Amino acid specificity
Lecture 21 Discovery of N-formyl Met
Lecture 22 Coupled transcription and translation
Section 6: Transcription Features
Lecture 23 RNA polymerase subunits
Lecture 24 Techniques used
Lecture 25 Promoter Melting
Lecture 26 Terms
Lecture 27 Polymerase specificity
Lecture 28 RNA phosphodiester bond formation
Lecture 29 Terms used
Lecture 30 Elongation
Lecture 31 Transcription termination
Section 7: Elucidation of genetic code
Lecture 32 Theoretical basis for codon triplets
Lecture 33 Overlapping/Non-overlapping nature of the genetic code
Lecture 34 Crick-Brenner hypothesis
Lecture 35 Experimental evidence for genetic code part 1
Lecture 36 Experimental evidence for genetic code part 2
Lecture 37 Experimental evidence for Crick-Brenner Hypothesis
Lecture 38 Crick brenner validation
Section 8: Course Summary
Lecture 39 Wrap up
Lecture 40 BONUS
High school students, college freshers and research students who are fascinated to know how this field evolved through unconventional ways of thinking and would like to get deeper insights into experimental strategies that led to important discoveries.,This course is not for absolute beginners who are looking for a typical molecular biology curriculum and also not for experts in the field who are looking for advanced knowledge .,This course would help research students in tapping into the collective historical wisdom of the pioneers, and use them as a guide in carving their own niche in further advancing this field.
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