Gene Editing Revolution Molecular Biology, CRISPR Systems

What you'll learn
Understand the structure and function of DNA, genetic inheritance, the genetic code, and protein synthesis
Explain endogenous DNA repair pathways and how they are exploited in gene editing
Describe the historical development of genetic engineering and early genome editing tools
Compare first-generation gene editing technologies such as ZFNs and TALENs with CRISPR-based systems
Understand the biological origins, components, and mechanisms of the CRISPR-Cas9 system
Explain the role of guide RNA, PAM sequences, and double-strand break formation in CRISPR editing
Distinguish between non-homologous end joining and homology-directed repair outcomes
Understand advanced CRISPR technologies including base editing, prime editing, CRISPRi, and CRISPRa
Identify viral and non-viral delivery methods used in gene therapy and research
Explore therapeutic, agricultural, and biotechnological applications of gene editing
Assess off-target effects, safety concerns, and limitations of genome editing technologies
Understand ethical principles, regulatory frameworks, and societal implications of gene editing
Requirements
An interest in biotechnology, genetics, medicine, or life sciences
No prior experience with CRISPR or gene editing technologies is required
Description
It's an Unofficial Course.This course provides a comprehensive and structured exploration of modern gene editing, guiding learners from the fundamental principles of molecular biology to the most advanced CRISPR-based technologies used today. It begins by building a strong foundation in DNA structure, genetic inheritance, the genetic code, protein synthesis, and endogenous DNA repair mechanisms, ensuring that learners clearly understand how genetic information is stored, expressed, and maintained within living systems.As the course progresses, learners are introduced to the historical development of genetic engineering and the early tools that laid the groundwork for contemporary genome editing. Classical techniques such as restriction enzymes and recombinant DNA technology are explained in detail, followed by an in-depth examination of first-generation programmable nucleases, including zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs). These topics help learners appreciate the evolution of precision, efficiency, and specificity in genome manipulation.A major focus of the course is the CRISPR-Cas9 system, where learners gain a clear understanding of its biological origins, molecular components, and functional mechanisms. The roles of Cas proteins, guide RNA design, protospacer adjacent motifs, and double-strand break formation are thoroughly discussed. The course also explains how cellular repair pathways, such as non-homologous end joining and homology-directed repair, are harnessed to achieve targeted genetic modifications.Beyond conventional CRISPR-Cas9 editing, the course explores advanced and next-generation CRISPR technologies that enable greater precision and control. Learners will study base editing, prime editing, and CRISPR-based gene regulation systems such as CRISPR interference and CRISPR activation. Various gene delivery strategies, including viral and non-viral methods, are examined to provide insight into how genome editing tools are introduced into cells for research and therapeutic purposes.The final portion of the course focuses on real-world applications and critical ethical considerations. Learners will examine the use of gene editing in treating monogenic diseases, the distinction between somatic and germline editing, and the expanding role of genome engineering in agriculture and biotechnology. Issues related to off-target effects, safety assessment, bioethical principles, and regulatory frameworks are addressed to encourage responsible and informed use of gene editing technologies. By the end of this course, learners will possess a well-rounded understanding of the science, applications, and ethical responsibilities associated with modern genome editing.Thank you
Who this course is for
Undergraduate and graduate students in biology, biotechnology, genetics, or related life science fields
Medical, pharmacy, and allied health students seeking foundational knowledge of gene editing technologies
Researchers and laboratory professionals who want a clear conceptual understanding of CRISPR and genome editing
Biotechnology and pharmaceutical professionals interested in modern genetic engineering applications
Educators and science enthusiasts who want to understand how gene editing works and its real-world impact
Beginners with a basic biology background who wish to enter the field of molecular genetics and genome editing
Homepage

https://www.udemy.com/course/gene-editing-revolution-molecular-biology-crispr-systems/

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